摘要
目的探讨载脂蛋白E基因与中国昆明地区汉族人阿尔茨海默病精神症状是否存在关联。方法运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,对58例无亲缘关系的中国昆明地区阿尔茨海默病患者及96例健康老年人,进行载脂蛋白E基因变异检测;采用神经精神量表(Neuropsychiatric Inventory Caregiver Distress Scale,NPI)评定患者的精神症状。结果AD组ε3/ε4基因型频率及ε4等位基因频率明显高于对照组(P<0.05);发现有妄想、抑郁心境、攻击行为症状组的ε4/x基因型频率及ε4等位基因频率高于无症状组,有幻觉症状组的ε4/x基因型频率及ε4等位基因频率低于无症状组,差异比较经χ2检验,均无统计学意义。结论ε4基因可能是AD的风险基因;ApoEε4等位基因与AD精神症状的发生并无关联。
Objective To study the relationship between polymorphisms of APOE gene and psychological symptoms in Alzheimer disease（AD）. Methods To examine＇the APOE genotypes and alleles in 58 AD patients and 96 healthy controls with PCR and restriction fragment length polymorphisms （RFLPs） technique. To estimate psychological symptoms in AD patients with the Neuropsychiatric Inventory Caregiver Distress Scale. Results The frequency of ε3/ε4 genotype and ε4 allele was significantly higher in AD group than in control group （P〈0. 05）; No statistically significant association between genotypes or alleles of apolipoprotein E and psychological symptoms was observed （P〉0.05）. Conclusion ε4 allele is probably one of the risk genes in the development of AD; There is no relationship between psychological symptoms and APOE genotypes or alleles.
出处
《中国健康心理学杂志》
2008年第10期1168-1170,共3页
China Journal of Health Psychology
