摘要
用RT－PCR方法检测55例乳癌组织多药耐药基因（MDR1），同时用ABC法测定其中50例肿瘤组织的雕、孕激素受体（ER、PR），结果MDR1阳性16例，阴性39例；ER阳性32例，阴性18例；PR阳性33例，阴性17例。经检验MDRI表达与ER、PR表达无根夫性。结论：乳癌患者存在体内癌细胞耐药状况，临床化疗时应考虑MDR1阳性的存在，选用敏感药物和加用耐药逆转剂。
With RT - PCR technique and immunohistochemical ABC method, MDR1, ER, PR in fresh operatived speciesmens of 55 breast cancer were measured. The results bave showed the positive expressions of MDR1, ER, PR appered n 16/55,32/50,33/50 cases respectivly. Statistical investigation shows that MDR1 expression is unrelated to the ER and PR expression. The slatus of MDR1 gene expression should be considered when we initiated chemotherapy for breast cancer.
出处
《苏州医学院学报》
1997年第6期1020-1021,共2页
Acta Academiae Medicinae Suzhou
关键词
多药耐药基因
激素受体
乳腺癌
Multidrug resistance
breast cancer
steroid receptor
