摘要
目的:探讨杏仁核电点燃癫痫对大鼠穿梭箱被动回避反应的记忆保持能力的影响。方法:大鼠每24h进行一次电刺激直至完全点燃,然后利用穿梭箱系统检测慢性电点燃癫痫对大鼠被动回避反应的记忆保持能力的作用;另一组动物于训练前5min给予杏仁核电刺激诱发癫痫大发作,观察癫痫的急性发作对记忆保持能力的作用。结果:在被动回避反应训练过程以及测试第1天,慢性点燃癫痫组和对照组动物进入暗箱的反应潜时没有明显差异;在测试第5天,慢性点燃癫痫组动物进入暗箱的反应潜时比对照组动物明显增加。另外,癫痫的急性发作使大鼠在测试第1天和第5天进入暗箱的反应潜时明显缩短。结论:慢性杏仁核电点燃癫痫可使大鼠被动回避反应的记忆保持能力增加,而癫痫的急性发作减弱了大鼠的记忆保持能力。
Objective： To investigate the effects of amygdala kindled seizures on memory retention of passive-avoidance test in rats. Methods： Chronic kindled seizures were achieved by daily application of electric stimulations on amygdala until the occurrence of 3 consecutive convulsive seizures. Then a passive-avoidance test was performed to measure memory retention ability in rats; another group of rats received an electric stimulation on amygdala 5 min before the training trail to observe the effects of acute seizure attack on memory retention ability. Results： In the training trail and the 1st day of the test trail,there was no difference in the latency to enter dark compartment between chronic kindled seizure group and its corresponding control group. However,the latency significantly increased at the 5 th day of test trail. In addition,the latency of acute seizure attack group rats significantly decreased at the 1 st day and 5 th day of test trail. Conclusion： Chronic amygdala kindled seizures increase memory retention of passive-avoidance test in rats,and acute seizure attack impairs this action.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2008年第5期463-467,共5页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金(No.30572176)
浙江省自然科学基金重点项目(No.Z207289)
