摘要
采用骨组织病理学方法对去势雌山羊骨组织结构变化进行动态观察。１．５岁左右雌性成都山羊１０只，平均体重２２ｋｇ左右，随机分为对照组５只，双侧卵巢切除组５只。术前，术后６０天，１２０天和１８０天分别取髂前上嵴骨活检组织作病理组织形态学观察。结果显示：在整个研究过程中对照组的骨组织结构维持相对恒定，而双侧卵巢切除组在术后６０天则出现轻度骨小梁数量减少，相互连接分离；术后１２０天到１８０天骨小梁数量进一步减少，骨小梁变细小，宽度降低，出现钮扣样变，骨髓腔扩大，呈典型的骨量减少的病理学改变。
Using histopatholoical method, we investigated the bone histomorphometric changes in ovariectomied goats at different time courses. Eight goats, female, aged one and a half years, were randomly divided into two groups, the control and the ovariectomy (OVX). Iliac crest biopsies were separately processed before ovariectomy and at 60 days, 120 days and 180 days after ovariectomy. The histomorphometric changes were observed. It was found that the bone structure in trabecular bone remained relatively constant in the control group throughout the whole study. In contrast, the trabecular quantity was slightly decreased and the trabeculae were disconnected in OVX at 60 days after ovariectomy. The bone structure was characterized by the thinning of the trabeculae, the further discontinuance and quantity loss of trabeculae, and the anlargement of marrow cavity at 120 days to 180 days after ovariectomy. Apparently, these bone structural changes manifested with typical osteopenia pathological changes. Our results may serve as a basis for the design of further studies using OVX goat as an animal model for postmenopausal osteoporosis.
出处
《华西医科大学学报》
CSCD
1997年第4期398-400,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
