摘要
幽门螺杆菌(Hpylori)是慢性胃炎,消化性溃疡的重要致病因素.研究表明,Hpylori的根治和清除有利于溃疡的治愈.而Hpylori耐药直接影响Hpylori的根治和清除,Hpylori耐大环内酯类药物(克拉霉素)的机制与他的23SrRNA的V区上的点突变有关.随着Hpylori耐药率的逐年升高,有关Hpylori的耐药分子机制和检测技术成为研究热点.因此,开展Hpylori耐药的相关研究对Hpylori的诊断和治疗有重大意义.
Helicobacter pylori （H pylori） infection is the main cause of chronic active gastritis and peptic ulcer disease, and studies indicated eradication of H pylori could promote the healing of peptic ulcer. H pylori resistance to clarithromycin, which shows an increasing tendency year by year, is related with mutations of H pylori 23S rRNA domain V. Molecular mechanism and detection technology of H pylori resistance to clarithromycin have become the focus of current researches. Investigations on H pylori resistance to antibiotics are of great significance for the diagnosis and therapy of H pylori infection.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第27期3060-3064,共5页
World Chinese Journal of Digestology
基金
江苏省医学重点建设学科资助项目
No.XK200723~~
关键词
幽门螺杆菌
耐药性
突变
克拉霉素
Helicobacter pylori
Resistance
Mutation
Clarithromycin
