摘要
目的探讨实时超声造影评价射频治疗子宫肌瘤的疗效及其应用价值。方法44例术前穿刺活检证实为子宫平滑肌瘤患者，分别于射频治疗前及治疗后1周进行实时超声造影检查，术后复查病理。术后1、3、6和12个月行随访及超声检查，比较治疗前、后肌瘤体积变化及临床症状变化。结果35例肌瘤治疗后超声造影显示病灶内“无灌注”，无灌注区与肌瘤大小相符；9例肌瘤周边有部分造影剂强化。病理结果证实：“无灌注区”组织坏死，造影剂部分强化区组织为不完全性坏死。治疗后3个月肌瘤开始缩小，6个月瘤体明显缩小，与治疗前比较差异有统计学意义（P〈0．05）。治疗后患者临床症状较术前有明显改善（占90％）。结论超声造影和随访观察证实射频治疗子宫肌瘤是一种有效的微创方法，实时超声造影能明确显示治疗范围及残存病灶，对于指导补充治疗有重要价值。
Objective To assess the value of contrast enhanced ultrasonography（CEUS） in evaluating the therapeutic efficacy of uterine leiomyoma treated by radiofrequency ablation（RFA） and to discuss the value of its application. Methods Forty-four patients which were diagnosed as uterine leiomyomas by ultrasonic guidance needle puncture biopsy preoperation were examined by CEUS before and one week after RFA treatment respectively,and the patho results were got again after the surgery. Routine ultrasonography was performed in 1 ,3,6,12 months after the treatment to compare the volume change of uterineleiomyomas with the change of the clinical symptoms. Results After the treatment, CEUS showed that the contrast agent didn＇t appear in thirty-five patients＇ uterine leiomyomas and the nonperfusion regions matched the size of the uterine leiomyomas completely. The contrast agent enhanced on the edge of the uterine leiomyomas in nine, the patho-resuhs confirmed that the nonperfusion regions of the contrast agent were necrosis tissues and the marginal local enhancement regions were incomplete necrosis. Three month after RFA treatment, the uterine leiomyomas began to shrink, which showed obviously in 6 months after the treatment. There were significant differences in the parameters before and after the treatment（ P 〈0. 05）. Clinical symptoms improved obviously in thirty five patients（90%） after the treatment. Conclusions RFA is an effective minimally invasive surgery of the uterine leiomyoma. CEUS can identify the treatment range and the remaining tissues, h has significant value in guiding the supplementary treatment.
出处
《中华超声影像学杂志》
CSCD
2008年第9期793-795,共3页
Chinese Journal of Ultrasonography
关键词
超声造影
微气泡
子宫肿瘤
平滑肌瘤
导管消融术
Uhrasonography
Microbubbles
Uterine neoplasms
Leiomyoma
Catheter ablation
