摘要
目的调查广州地区城乡年龄≥60岁老人中轻度认知障碍(MCI)的患病率。方法用分层随机整群抽样方法抽样,采用筛查和确诊两阶段法进行调查,实查年龄≥60岁老人4697人,失访率4.9%。MCI诊断需符合Petersen的诊断标准及临床痴呆程度评定量表(CDR)评分等于0.5。结果①检出MCI患者257例,粗患病率为5.47%,经广州市2000年人口年龄构成标化,MCI的患病率为4.94%;②其中男女MCI患者分别为67例和190例,女性粗患病率显著高于男性(6.87%vs 3.47%,P<0.001),年龄标化患病率分别为6.51%和2.90%;③MCI患病率随年龄的增加而增高(P<0.001);④城区MCI粗患病率略低于农村,但差异无统计学意义(5.22%vs 6.66%,P>0.05);⑤有脑血管病史患者MCI的患病率高于无脑血管病史的老人(10.93%vs 5.08%,P<0.001)。⑥血管性非痴呆认知障碍(VMCI)的患病率为0.72%,男女两性的患病率差异无统计学意义(P>0.05)。结论MCI患病率随年龄增长而增高,女性高于男性,有脑血管病史者患病率较高,提示高龄、女性、有脑血管病史是MCI的易感因素。
Objective To study the prevalence of the mild cognitive impairment （MCI） among aged 60 years and over elderly people in Guangzhou. Methods A total of sample of 4939 elderly people aged 60 or above living in Guangzhou area were randomly stratified sampled out from three levels of 12 districts in Guangzhou, in which 4697 were interviewed, using a two-stage screening and diagnosis of investigation, with the dropout rate of investigated 4. 90%. The diagnosis of MCI was made according to the Petersen＇s criteria, and their clinical dementia rating （CDR） score equal 0. 5. Results ① Two hundred fifty-seven cases of mild cognitive impairment were identified, The crude prevalence of MCI was 5.47% and the age-standardized prevalence of MCI was 4. 94%. ②The male and female patients with MCI were 67 cases and 190 cases, respectively. The crude prevalence rate was significantly higher in female than in male （6. 87% vs 3.47%, P 〈0. 001 ）, standardized prevalence rates was 6. 51% and 2. 90% respectively;③The prevalence of MCI was increasing with age advancing（ P 〈 0. 001 ）. ④The crude prevalence was slightly lower in urban than in rural, but the difference was no significant. （5.22% vs 6. 66% ,P 〉0. 05）. ⑤The prevalence of MCI in the patients with a history of cerebrovascular disease was significantly higher than that in patients without a history of cerebrovascular disease（ 10. 93% vs 5. 08% ,P 〈0. 001 ）. ⑥The prevalence of vascular mild cognitive impairment （VMCI） was 0. 72%, which were not significantly different between male and female（P 〉 0. 05 ）. Conclusions The prevalence of dementia increases with increasing age. The prevalence of MCI is higher in female than in male. The prevalence of MCI in the elderly with history of eerebrovascular disease is higher. Persons with advance age, female or the history of cerebrovacular disease are at high risk of developing MCI.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2008年第9期533-537,共5页
Chinese Journal of Nervous and Mental Diseases
基金
广州市科学技术委员会攻关项目(编号:2000-2-026-01)
关键词
轻度认知障碍
患病率
老年人
社区
Mild cognitive impairment Prevalence Aged Community
