摘要
目的:探讨膀胱移行细胞癌(BTCC)的CT分期与Ki-67和微血管密度(MVD)表达的关系。方法:对56例经手术病理证实的BTCC,采用LDP免疫组化法,检测肿瘤标本中Ki-67和MVD表达,并分析其与术前CT分期的关系。结果:①Ki-67 LI与MVD计数呈显著的正相关关系(r=0.583,P=0.000);②不同病理分级间Ki-67LI、MVD计数均有显著性差异(F值分别为18.599、21.951,P均<0.05);③不同CT分期间Ki-67LI、MVD表达总的来说有差别(F=7.912、6.744,P<0.05),经两两比较除Ⅰ期与Ⅱ期无差别(F=-5.23、0.23,P=0.537、0.955)外,Ⅰ期与Ⅲ期、Ⅰ期与Ⅳ期、Ⅱ期与Ⅲ期、Ⅱ期与Ⅳ、Ⅲ期与Ⅳ期比较均有显著性差异(P均<0.05)。结论:BTCC的CT分期、病理分级与Ki-67和MVD的表达具有相关性,能较为客观、准确的反映BTCC的恶性程度,对选择治疗方法有重要的参考价值。
Objective：To investigate the relationship between CT staging and the Ki-67 expression and the microvessel density （MVD） in bladder transitional cell carcinoma（BTCC）. Methods：The expression of Ki-67 and MVD were estimated with labeled dextran polymer （LDP） immunohistochemical techique in 56 cases with surgery and pathologically proved BTCC, and the relation between CT staging and the expression of Ki-67 and MVD was retrospectively analyzed. Results：① Ki-67 index correlated positively with MVD （ r = 0.583, P = 0.000） ; ② There was significant difference between Ki-67 index and MVD expression with different pathological grading （ F = 7.912,6. 744, P 〈 0.05） ; ③ The expression of the Ki-67 and MVD had significant difference with the different groups by CT staging in totality （ F = 7.912,6.744, P 〈 0.05）. Conclusion：Tbe CT staging and pathological grade is related to the expression of Ki-67 and MVD of the BTCC, so this can reflect the malignant degree of BTCC accurately and will be helpful to the clinical diagnosis and treatment.
出处
《医学影像学杂志》
2008年第9期1043-1047,共5页
Journal of Medical Imaging
