摘要
近年来,随着自体腘绳肌腱前交叉韧带重建术的广泛开展,腱-骨愈合的影响因素和促进方法成为运动医学研究的热点。影响腱-骨愈合的相关因素主要包括移植物的固定方式、骨的性质、应力刺激以及移植肌腱与隧道的匹配关系等,促进腱-骨愈合的方法主要包括生长因子、金属蛋白酶阻断剂、骨保护素等试剂和间充质干细胞、物理方法的运用。目前在促进腱-骨愈合方面已探索出一些较有潜力的方法,但是这些方法大多数尚处于动物实验阶段或者牵涉到复杂的实验室技术,在进入临床应用之前,对这些方法的可行性尚需进一步的研究。
Presently, with anterior cruciate ligament reconstruction using autogeneic hamstring tendon graft is generally developed, the influencing factors and promotion methods of tendon-bone healing become a research focus of sports medicine. The influencing factors include the graft fixation, the character of bone, stress stimulation and the matching relation between graft and bone tunnel and so on. The promotion methods include applying growth factors, metalloprotease blocking agent, osteoprotegerin, mesenchyme stem cells, physical methods. Some prospective methods of promoting tendon-bone healing have been found, but these methods are in animal study or involving complex laboratory technique. Thus, these methods require further studies before clinical application.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第37期7359-7363,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
