摘要
分化抑制因子(inhibitor of differentiation,Id)是广泛表达的螺旋-环-螺旋(helix-loop-helix,HLH)家族成员中参与负性调节的转录因子,在真核生物中,Id蛋白在发育、调控细胞增殖和分化、肿瘤血管形成、侵袭性以及转移等方面有着重要的作用.最近的研究表明,Id表达不仅和肿瘤形成、进展以及预后相关,而且有望成为肿瘤治疗的新靶点.综述了Id在肿瘤发生发展过程中可能的机制、作用以及在肿瘤靶向治疗中的前景.
The ubiquitously expressed family of Id（inhibitor of differentiation） helix-loop-helix （HLH） proteins function as dominant negative regulators of basic HLH （bHLH） transcriptional regulators. In eukaryotic organisms, Id proteins have been implicated in development, cell differentiation, proliferation, angiogenesis, invasion and migration. Recent studies revealed that Id proteins are not only significantly correlated with cancer progression and prognosis, but also exploited as a tumor therapeutic target. The roles of Id proteins in tumorigenesis were reviewed and the opportunities of Id proteins in cancer targeted therapy were discussed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2008年第9期986-990,共5页
Progress In Biochemistry and Biophysics
基金
江苏省六大人才高峰基金课题资助项目(050203D)~~
关键词
分化抑制因子
肿瘤
靶向治疗
inhibitors of differentiation, cancer, targeted therapy
