摘要
目的:通过观察中药对中枢神经递质受体表达的影响,探讨中药治疗情志障碍及经前期综合征(PMS)的微观机制。方法:脉冲电流结合噪音刺激大鼠,造成肝气逆PMS模型。分别给予生理盐水、经前平颗粒灌胃,连续4个月经周期,免疫组化法检测海马β-内啡肽阳性细胞。结果:处于发情期的PMS大鼠β-内啡肽(β-EP)阳性细胞表达显著低于同一月经周期的正常鼠(P<0.05),经前平颗粒能够缓解焦虑症状,且可以使大鼠海马β-内啡肽阳性细胞明显增多(P<0.05)。结论:中药经前平颗粒可能通过调节中枢β-内啡肽的表达,而治疗与PMS有关的情志障碍。
Objective：To explore the micromechanism on feeling obstacle and premenstrual syndrome（PMS） by observing traditional Chinese medicine on the expression of the neurotransmiter receptor in neutron. Methods： To make the PMS model rat with liver-Qi invasion by stimulating the rat with pulse electric current and noises, then give the model rat differ- ent medicine for four menstrual periods, and check the positive cell of β-EP receptor in the rat hippocampi by irnmunohistochemistry method. Results： The positive cell expression of β-EP significantly lower in hippocampi of PMS model rat in the stage of oestrum than that of normal rat （P 〈 0.05 ）, Jingqianping granule can lower the anxiety symptom, and significantly increase the positive cell of β-EP of PMS rat model（ P 〈 0.05）. Conclusion： Jingqianping granule could treat feeling obstacle related with PMS by controlling the expressin of β-EP receptor in central nervous system.
出处
《山东中医药大学学报》
2008年第5期426-427,共2页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(编号:30171131)
山东省自然科学基金资助项目(编号:Z2003C01)
