摘要
为探讨苦参素对活化的肝星状细胞整合素αV表达和失巢凋亡的影响,把培养激活的HSC-T6分为对照组及实验组,实验组以不同浓度的苦参素干预(分别为30、60、120、240、480、960 mg/L),W estern b lot检测整合素αV的表达,结果发现药物干预后整合素αV的表达逐渐降低(分别降低18.4%、30.5%、39.8%、52%、62.3%、76.5%,P<0.05),且呈浓度依赖性(r=-0.76),表明苦参素能通过抑制整合素αV的表达来影响肝纤维化的发展。
To explore the effect of Kwoninone on the expression of integrin αv and anoikis in HSC-T6. HSC-T6 cells were treated with Kwoninone in different concentration（30, 60, 120, 240, 480 and 960 rag/L, respectively） or without treatment as enntrnl. The expression of integrin αv in various groups were detected by Western blot. The expression of integrin αv in Kwoninone treated cells significantly decreased. The decrease was in dose-dependent manner comparing with the control group（ P 〈 0.05）. Kwoninone can suppress the expression of integrin α.
出处
《胃肠病学和肝病学杂志》
CAS
2008年第9期737-737,740,共2页
Chinese Journal of Gastroenterology and Hepatology
