幽门螺杆菌毒力因子与儿童胃肠疾病的关系
The relationship between helicobacter pylori virulence factors and gastrointestinal diseases of children
摘要
幽门螺杆菌(Hp)感染是慢性活动性胃炎和消化性溃疡的主要病因。Hp感染儿童后常常引发胃肠疾病,如慢性胃炎、胃溃疡、功能性消化不良等。通过对Hp相关毒力因子(VacA、CagA、iceA)的不同基因型和儿童宿主胃肠疾病相互关系的国内外研究现状进行分析后发现,检测Hp感染患儿毒力因子不同基因型的分布情况,研究其对临床指标的作用影响,对于确定Hp毒力标志,评估儿童临床病情及预后具有着重要意义。同时发现,儿童背景基因及细胞因子的基因多态性部分决定着宿主对Hp感染的临床转归。
出处
《国际儿科学杂志》
2008年第5期479-481,共3页
International Journal of Pediatrics
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