摘要
将两种形态的AZ31B镁合金(条型内固定板和片状多孔板)植入实验动物(新西兰兔)体内,并以钛合金板作为对照,研究了镁合金在修复实验动物下颌骨表面不同形态骨缺损时的骨诱导作用.结果表明,镁合金条形内固定板植入90和180d后,周围有新骨生成,新骨生成量高于对照组;而片状多孔板植入180d后,其下方出现不同程度的成骨和溶骨.AZ31B镁合金具有明显的诱导动物机体新骨生成的能力;但当镁合金降解产生的局部镁离子浓度过高时,则会引起局部的溶骨反应.
AZ31B magnesium alloy supports and Ti 6A1-4V supports as controls with two dimensions （stabilization splint and dictyo-plate） were implanted on submaxilla surfaces of the New Zealand rabbits. The bone induction role by AZ31B in healing of two different kinds of bone coloboma on the submaxilla surface was studied. It was found from the experiments after 90 and 180 d implantations that formation of the new bone around the AZ31B stabilization splint was much more obvious than the control group. After 180 d implantation, both newly formed bone and osteolysis were found on the surface of the dictyo-plate implants. It can be concluded that magnesium alloy implantation is beneficial to the new bone formation, but overdosed magnesium ions from biodegradation can also lead to the increase of osteoclast activity.
出处
《金属学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第9期1035-1041,共7页
Acta Metallurgica Sinica
基金
中国科学院知识创新工程重要方向资助项目KGCX-YW-207~~
关键词
镁合金
生物可降解
植入
骨诱导
magnesium alloy, bio-degradable, implantation, bone induction
