摘要
目的:探讨不同运动方式对肥胖青少年人群胰岛素抵抗和胰岛β细胞功能的影响。方法:以100例年龄、性别相配对的健康志愿者为对照,观察游泳、步行、举哑铃及仰卧起坐各25例以4种不同运动方式持续运动1h前、后肥胖青少年患者血糖、胰岛素水平和血乳酸的变化,并根据稳态血糖模型(Homa模型)计算出其反映胰岛素抵抗和胰岛β细胞功能的指标变化。结果:1)运动前肥胖组患者其BMI、腰围、腰臀比、IAI、IR均显著高于正常对照组(P<0.05,或P<0.01),而IS、HBCI、血乳酸则在两组间均无显著性差异(P>0.05)。2)与运动前相比较,肥胖患者中经1h游泳及1h步行的患者,其反映胰岛素抵抗的指标即IR有显著下降(P<0.01),IAI有显著升高(P<0.01),而反映胰岛β细胞功能状态的指标,即IS和HBCI有显著提高(P<0.05),血乳酸水平有轻微增加,但无显著性差异(P>0.05)。举哑铃及仰卧起坐1h后,IR也有显著下降(P<0.05),IAI有显著升高(P<0.05),IS和HBCI有一定程度提高,但无显著性差异(P>0.05),血乳酸水平有显著性升高(P<0.01)。3)在肥胖组中游泳亚组和步行亚组IR显著低于举哑铃及仰卧起坐亚组(P<0.05),IAI、IS和HBCI较举哑铃及仰卧起坐亚组高,但均无显著性差异(P>0.05),而血乳酸则显著低于举哑铃及仰卧起坐亚组(P<0.05)。4)肥胖患者IR与BMI、腰围、腰臀比均呈显著正相关(其相关系数分别为0.5768,0.6059,0.7987,均P<0.05);IAI分别与BMI、腰围、腰臀比均呈显著负相关(其相关系数分别为-0.6635,-0.6278,-0.7523),而IS则与BMI、腰围、腰臀比等无显著相关关系。结论:有氧运动能显著改善肥胖患者胰岛素抵抗,并能在一定程度上保护患者自身胰岛β细胞功能,而无氧运动对其效果较差。
The purpose of this study was to analyze the effects of different exercise on insulin resistance and insulin beta cell function of obese teenagers. The variation of 25 obese teenag ers＇ blood sugar, insulin level and blood lactic acid was observed before and after one hour＇s different exercise such as swimming, walking, dumbbell raise and sit ups and the variation of insulin resistance and insulin beta cell function indexes was calculated according to the Homa model, comparing with 100 age and gender matched normal volunteers. The result shows that 1. the BMI, waistline, buttock, IAI, IR of obese teenagers before exercise are much higher than those of normal ones （P〈0.05 or P〈0.01） ,while there are obvious differences in IS, HBCI and blood lactic acid between the two groups （P〉0.05）. 2. The obese teenagers＇ insulin resistance indexes vary after one hour＇s swimming and walking. IR falls remarkably （P〈0.01） while IAI rises remarkably （P〈0.01）. The variation of insulin beta cell function indexes are as follows： IS and HBCI rise evidently （P〈0. 05）, while blood lactic acid level increases slightly （P〉 0.05）. After one hour ＇s dumbbell raise and sit- ups exercise, IR falls remarkably （P〈0.05） while IAI rises remarkably （P〈0.05）. IS and HBCI rise slightly （P〉0.05）. Blood lactic acid rises obviously （P〈0.01）. 3. Among the fat teenagers, IR in the swimming and walking group is much lower than the dumbbell raise and sit-ups group （P〈0.05）. IAI, IS and HBCI are higher but not remarkably （P〉0.05）. Blood lactic acid is much lower （P〈 0. 05）. 4. Direct correlation is remarkably observed between IR of fat teenagers and BMI, waistline, buttock ratio （ the related coefficients are 0. 5768,0. 6059,0. 7989, P 〈 0. 05）. Negative correlation is observed between IAI and BMI, waistline and buttock ratio. It concludes that aerobic exercise greatly improve insulin resistance of obese patients and protect their insulin beta cell function whi
出处
《中国体育科技》
CSSCI
北大核心
2008年第5期134-137,共4页
China Sport Science and Technology
关键词
肥胖
青少年
运动
胰岛素抵抗
胰岛Β细胞功能
obese
teenagers
exercise
insulin resistance
insulin beta cell function
