摘要
目的研究伊曲康唑治疗恶性血液病合并侵袭性真菌感染的疗效。方法回顾性分析2005年1月至2007年3月南方医科大学南方医院血液科127例恶性血液病合并侵袭性真菌感染患者应用伊曲康唑治疗的疗效。结果伊曲康唑临床总有效率47.2%(60/127)。在确诊、临床诊断和拟诊组病例的有效率分别为66.7%(16/24)、51.6%(33/64)、28.2%(11/39),拟诊组明显低于确诊和临床诊断组(P<0.01)。副反应轻微。伊曲康唑对检出菌株,接受移植、使用免疫抑制剂及负荷量给药的患者有效率明显高于对照组(P<0.05和P<0.01)。结论伊曲康唑治疗恶性血液病合并侵袭性真菌感染有良好的疗效,且安全可靠。
Objective To investigate the efficacy of itraconazole in the treatment of malignant hematological diseases with invasive fungal infections. Methods Retrospectively analyze the efficacy of itraconazole in the treatment of 127 malignant hematological patients in the Department of Hematology of Nanfang Hospital of Southern Medical University. Results The total efficacy rate of itraconazole was 47.2% （60/127）. The efficacy rates in the patients with confirmed diagnosis, with clinical diagnosis and with recommended diagnosis were 66. 7% （16/24） ,51.6% （33/64） ,28.2% （11/39 ）respectively. The efficacy rate of recommended group was obviously lower than confirmed group and clinical group（P 〈 0. 01 ）. The adverse side effect of itraconazole was little. The efficacy rates in groups which were checked out fungus, accepted transplantation, used immunosuppressive agent and treated with loading dose of itraconazole were higher than control group （ P 〈 0. 05 and P 〈 0. 01 ）. Conclusion Itraconazole is effective and safe in the treatment of malignant hematological diseases combined with invasive fungal infections.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2008年第9期796-798,共3页
Chinese Journal of Practical Internal Medicine
关键词
伊曲康唑
恶性血液病
侵袭性真菌感染
itraconazole
malignant hematological diseases
invasive fungal infections
