摘要
目的:探讨氢质子磁共振波谱(1H-MRS)在轻度认知障碍(MCI)、Alzheimer病(AD)诊断中的作用。方法:对20例MCI患者、20例AD患者、20例正常对照者(NC)行单体素1H-MRS检查,采用激励回波采样模式(STEAM),大小为2cm×2cm×2cm,测定后扣带回、左额中回皮质区、左枕叶皮质区的N-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌醇(mI)与肌酸(Cr)的比值,并比较各组间NAA/Cr、mI/Cr、Cho/Cr比值的差别。结果:在后扣带回、左额中回皮质区,AD组与MCI组、AD组与NC组间NAA/Cr有显著性差异(P<0.05),MCI组、AD组、NC组3组间mI/Cr有显著性差异(P<0.05)。结论:在后扣带回、左额中回皮质区,MCI患者仅有mI/Cr增高,而AD患者mI/Cr增高的同时伴有NAA/Cr下降。1H-MRS能无创性提供MCI、AD患者脑部的代谢情况,有助于MCI、AD的早期诊断。
Objective： To evaluate the role of proton magnetic resonance spectroscopy （^1H-MRS） in the diagnosis of mild cognitive impairment（MCI） and Alzheimer＇s disease（AD）. Methods： A single voxel ^1H-MRS studies were performed to 20 patients with MCI, 20 patients with AD, and 20 normal control volunteers. The mode of spectral acquisition was STEAM technique, localizing 2cm×2cm×2cm voxels in the posterior eingulate gyri, the middle frontal gyrus cortex and the left occipital cortex. The metabolites in the spectra collected for quantification included N-acetyl aspartate（NAA）, choline（Cho）, creatine（Cr） and myo-inositol （ml）. The ratios of NAA/Cr, mI/Cr and Cho/Cr were calculated and compared among the groups. Results： NAA/Cr of the posterior cingulate gyri and the middle frontal gyrus cortex region in AD-MCI group, AD-NC group were significantly different （P〈0.05）. mI/Cr of the posterior cingulate gyri and the middle frontal gyrus cortex region in AD, MCI and NC groups were significandy different（P〈0.05）. Conclusion： We found the reduction of NAMCr ratio and the increase of mI/Cr ratio in the posterior cingulate gyri and the middle frontal gyrus cortex in patients with AD, but only the increase of mI/Cr ratio in patients with MCI. ^1H-MRS could provide biochemical and metabolic information on patients with MCI and AD noninvasively, which is helpful for the early diagnosis of MCI and AD.
出处
《中国临床医学影像杂志》
CAS
北大核心
2008年第9期612-615,共4页
Journal of China Clinic Medical Imaging
基金
上海交通大学"医工(理)交叉研究基金"项目(YG2007MS15)
关键词
认知障碍
阿尔茨海默病
磁共振波谱学
Cognition disorders
Alzheimer disease
Magnetic resonance spectroscopy
