摘要
目的评价格列吡嗪盐酸二甲双胍片(降血糖药)的疗效及安全性。方法用多中心、随机、双盲双模拟临床研究,试验组120例,二甲双胍组、格列吡嗪片组各60例,治疗12周。结果治疗前后试验组较二甲双胍组HbAlc多降低了0.78%,较格列吡嗪组多降低了0.41%(P<0.001);治疗前后试验组较二甲双胍组空腹血糖多降低了0.97 mmol·L^(-1),较格列吡嗪组多降低了1.36 mmol·L^(-1)(P<0.001);低血糖发生率3组相似。结论格列吡嗪盐酸二甲双胍与单药治疗相比,降低HbAlc、空腹及餐后2 h血糖均更为明显,且耐受性很好。
Objective To assess effects and tolerance of glipizide/metformin hydrochloride combination tablets in patients with type 2 diabetes mellitus. Methods A muhieenter, double - masked, parallel - group, double - mimic active - controlled study was performed in 5 centers in China. One hundred twenty patients received glipizide/metformin hydrochloride tablets, 60 patients received glipizide or metformin respectively for 12weeks. Results Glipizide/metformin hydrochloride tablets controlled the HbAlc level more effectively than did either glipizide or metformin monotherapies （ mean treatment differences, in favor of glipizide/ metformin, of -0.41% and -0.78% , respectively,P 〈 0. 001 ）. Glipizide/metformin hydrochloride tablets also reduced the fasting plasma glucose （FPG） more effectively than did either glipizide or metformin monotherapies （mean treatment differences, in favor of glipizide/metformin, of -1. 36 mmol · L^-1 and -0.97 mmol · L^-1, respectively, P 〈 0. 001 ）. Treatments were well tolerated, with a similar low incidence of symptoms of hypoglycemia in every group . Conclusion Glipizide/metformin hydrochloride tablets were more effective than either glipizide or metformin monotherapy in treating type 2 diabetes and had well tolerance.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2008年第5期387-391,共5页
The Chinese Journal of Clinical Pharmacology
