摘要
目的探讨霞水母来源的胶原对大鼠佐剂型关节炎的治疗作用。方法采用完全弗氏佐剂造成大鼠关节炎模型,致炎后大鼠给予霞水母胶原连续灌胃14d,观察大鼠双后肢关节肿胀情况,及对血清中一氧化(?) (NO),超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。结果口服霞水母胶原可以降低大鼠的双后肢关节肿胀度,降低大鼠血清中NO和MDA含量,提高大鼠血清中SOD活性。结论霞水母胶原对佐刺型关节炎有较好的治疗作用,其机理可能与降低体内氧自由基水平及过氧化脂质水平有关。
Objective To investigate the suppressive effects of collagen from Cyanea nozakii on adjuvant induced arthritis in rat. Methods Rats with adjuvant arthritis received different doses of Cya,zea nozakii collagen by intragastric administration for two weeks. Incidence and severity of arthritis were assessed by calculation of mean arthritis index, the concentrations of NO, MDA and activity of SOD in the serum were examined. Results Cyanea nozakii collagen at different doses could ameliorate the adjuvant induced arthritis, suppress the concentrations of NO, MDA and increase the activity of SOD in the serum. Conclusion Cyanea nozakii collagen has therapeutic efficacy in treatment of adjuvant arthritis rats, and the mechanism of Cyanea nozakii collagen is probably related to the antioxidation.
出处
《中国海洋药物》
CAS
CSCD
2008年第4期35-38,共4页
Chinese Journal of Marine Drugs
基金
国家农业科技成果转化资金(No.2007GB2C100105)
关键词
霞水母
胶原
佐剂型关节炎
抗氧化
Cyanea nozakii
collagen
adjuvant arthritis
antioxidation
