摘要
目的分析产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌、大肠埃希菌的耐药性,指导临床合理用药。方法采用API鉴定系统进行菌株鉴定及药敏试验。结果2种细菌ESBLs总阳性检出率为60.2%(153/254);肺炎克雷伯菌ESBLs为60.2%(53/88);大肠埃希菌为60.2%(100/166);产ESBLS菌株对青霉素类和头孢类抗菌药物大多耐药,仅对美罗培南非常敏感,产ESBLs菌株对抗菌药物的耐药率高于非产ESBLs菌株。结论医院及时监测产ESBLs菌的发生率及其耐药趋势以指导临床用药至关重要。
Objective To investigate the antibiotic resistance of Escherichia Coli and Klebsiella pneumonia producing extended-spectrum β-1actamases （ESBLs） and to guide the clinical administration of drugs. Methods API half-automicroscan system was used to identify the pathogenic bacteria and conduct drug resistance test. Results The detection rate for ESBLs was 60.2% in both E. Coli and K. pneumoniae, 60.2%（53/88） in K. pneumonia and 60.2% （100/ 166） in E. coli. ESBL producing strains were more resistant to penicillins and cephalosporins, but sensitive to meropenem. The resistance rate of ESBL producing strains to antibacterial agents was higher than that of non-ESBL producing strains. Conclusion Detecting ESBI, strain producing rate and their susceptibility to antibiotics is are very important in guiding the clinical administration of drugs.
出处
《中南药学》
CAS
2008年第5期630-632,共3页
Central South Pharmacy
