摘要
目的探讨1980年～1984年（简称1980组）和1994年～1996年（简称1994组）两组年轻乳腺癌患者（≤35岁）生存状况的变化及其相关临床因素。方法回顾性分析≤35岁原发性乳腺癌179例，均随访5年，随访率100．0％，比较两组生存率并探讨临床病理因素对生存率的影响。结果1980组和1994组5年生存率分别为59．8％（52／87）、78．3％（72／92），5年健在率分别为51．7％（45／87）、75．0％（69／92），两组比较有显著性差异（P〈0．01）。1994组Ⅰ、Ⅱ期病例及淋巴结阴性率均高于1980组（79．4％，60．9％，P〈0．01和59．8％，42．5％，P〈0．05），并且生存率改善主要为Ⅰ、Ⅱ期病例。1994组行保乳手术例数明显增加，行经典根治术例数减少（P〈0．01）。结论1994组年轻乳腺癌生存率显著改善，手术范围扩大不体现生存优势，提高生存率的关键是早期诊断及治疗，并非完全依赖治疗手段。
Objective To study the changes in survival and the relative clinical factors in two cohorts of young patients with breast cancer （ ≤ 35-year-old） between 1980 - 1984 （1980s） and 1994 - 1996 （1990s）. Methods The data of 179 patients with primary breast cancer （ ≤ 35-year-old） were analyzed retrospectively. The patients were followed for 5 years with a follow-up rate of 100.0%. The survival rate in two cohorts was compared and the influence of the clinicopathological factors on survival was analyzed. Results The 5-year survival rate in 1980s and 1990s were 59.8% （52/87） ,78.3% （72/92） ,respectively, and the 5-year disease-free survival rate were 51.7% （45/87） and 75.0% （69/92）, which were significantly different （P 〈 0.01 ）. The proportion of stage Ⅰ , Ⅱ and node-negative in 1990s was higher than that in 1980s （79.4% VS 60.9%,P 〈 0.01 and 59.8% VS 42.5% ,P 〈0.05）. The patients with stage Ⅰ , Ⅱ had a better survival rate. The rates of breast-conserving therapy increased dramatically in 1990s（ P 〈 0.01 ）. Conclusion The survival rate for young patients with breast cancer has significantly improved in 1990s. Extended operations do not benefit the survival. The improvement of survival is mostly based on early diagnosis and treatment.
出处
《实用癌症杂志》
2008年第5期486-488,495,共4页
The Practical Journal of Cancer
基金
天津医科大学科学基金(2004KY48)资助
关键词
乳腺癌
生存率
临床因素
Breast cancer
Survival rate
Clinical factor
