摘要
一般认为志贺菌产生耐药性与抗菌药的结构和作用机制有关,并通过质粒携带的耐药基因扩散耐药性,同类结构药物或作用机制相似的药物具有部分或全部交叉耐药性。然而,近几年随着分子生物学手段的不断应用,人们开始从更多层面来认识志贺菌的耐药性。细菌对不同结构类别或不同作用机制的抗菌药物都能产生耐药性,即多重耐药(mu lti-drug resistance)。本文就志贺菌耐药机制的研究进展进行了综述。
It is generally considered that the antibiotic resistance of Shigella spp. is related to the structure and function mechanism of the drug and can be propagated through the antibiotic resistance related genes carried by plasmid. Therefore, S. spp. possess cross-tolerance of the drugs with similar structure or function mechanism. Nevertheless, in recent years along with the application of molecular biology methods, people have obtained more and more knowledge about antibiotic resistance of S. spp. from more aspects. The bacterium can have antibiotic resistance against the antibiotics with different structures or different function mechanism, namely multi-drug resistance. In this article, recent studies on molecular mechanism of multi-drug resistance in S. spp. were summarized.
出处
《云南农业大学学报（自然科学版）》
CAS
CSCD
2008年第5期683-686,共4页
Journal of Yunnan Agricultural University:Natural Science
关键词
志贺菌
耐药
多重耐药
Shigella spp.
antibiotic resistance
multi-drug resistance
