处于临床研究阶段可预防人免疫缺陷病毒性传播的杀微生物剂
摘要
艾滋病(acquired immunodeficiency syndrome,AIDS)是由人免疫缺陷病毒(human immunodeficiency virus,HIV)感染引起的一类传染性疾病,目前全球仍有近4000万例感染者,是威胁人类健康的第一大单一病因疾病。由于艾滋病疫苗的问世尚需时日,要想彻底遏制HIV的传播,必须找到一种新的高效、价廉的途径。而杀微生物剂(microbicides)就是这样一条被国际社会寄予厚望的HIV预防途径。
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2008年第9期690-693,共4页
Chinese Journal of Preventive Medicine
基金
教育部高等学校科技创新工程重大项目培育基金(706047)
广州市科技攻关项目(200522-E4041)
参考文献19
-
1Balzarini J, Van Damme L Microbicide drug candidates to prevent HIV infection. Lancet, 2007,369:787-797. 被引量:1
-
2Jiang S, Liu S, Stone A. China needs safe and effective microbicides for preventing sexual transmission of HIV. Lancet Infect DIS,2006, 6: 681-682. 被引量:1
-
3Stone A. Microbicides: a new approach to preventing HIV and other sexually transmitted infections. Nat Rev Drug Discov,2002, 1:977-985. 被引量:1
-
4Lederman MM, Offord RE, Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol,2006,6:371-382. 被引量:1
-
5D'Cruz OJ, Uckun FM. Clinical development of microbicides for the prevention of HIV infection. Curr Pharm Des, 2004, 10: 315-336. 被引量:1
-
6Hillier SL, Moench T, Shattock R, et al. In vitro and in vivo:the story of nonoxynol 9. J Acquir Immune Defic Syndr,2005,39 : 1-8. 被引量:1
-
7World Health Organization. WHO/CONRAD technical consuhation on nonoxynol-9, World Health Organization, Geneva, 9-10 October 2001: summary report. Reprod Health Matters, 2002,10(20) : 175-181. 被引量:1
-
8Roy S, Gourde P, Piret J, et al. Thermoreversible gel formulations containing sodium lauryl sulfate or n-lauroylsarcosine as potential topical microbicides against sexually transmitted diseases. Antimicrob Agents Chemother,2001,45 : 1671-1681. 被引量:1
-
9Ballagh SA, Baker JM, Henry DM, et al. Safety of single daily use for one week of C31G HEC gel in women. Contraception, 2002,66:369-375. 被引量:1
-
10Annette L. Phase Ⅲ trials of cellulose culfate microbicide for HIV prevention closed [ EB/OL ] . [ 2007-01-31 ] . http:// www. conrad. org/press/phaseⅢtrials. htm. 被引量:1
-
1抗逆转录病毒药预防艾滋病有新证据[J].医药前沿,2016,0(20):2-2.
-
2李林,李敬云.影响艾滋病病毒性传播的生物学因素[J].中华流行病学杂志,2003,24(10):947-950. 被引量:7
-
3丁荣晶.查血中硒含量 保护心血管健康[J].医药前沿,2011(6):48-48.
-
4刘中辉,彭俊生.胃溃疡“顽固”或许已变“癌”[J].家庭药师,2009(8):44-45.
-
5阚宗兵.餐后血糖高宜吃粗粮[J].医药前沿,2014(19):64-64.
-
6柳鹏.让老年人远离饮食误区[J].健康世界,2011(12):96-97.
-
7秦春梅,刘波,沈轶,吴广飞,陆强,尹福在.有无家族史的2型糖尿病患者应用胰岛素泵治疗的临床疗效比较[J].中国医师进修杂志(内科版),2007,30(9):7-8.
-
8李远,孙明昌.系统性红斑狼疮合并急性胰腺炎1例[J].江西医药,2012,47(6):501-502.
-
9徐英.ARB平稳降压待时日[J].中国医院院长,2008(17):64-65.
-
10戴芬,梁雪梅,敖小敏,何燕伶.浅谈艾滋病单阳家庭患者的心理问题与干预[J].中国实用乡村医生杂志,2014(15):17-18. 被引量:1