摘要
雷莫拉宁(Ramoplanin、A16686、MDL62,198)是一种新型的糖肽类抗生素,能够特异而迅速地抑制革兰氏阳性菌细胞壁的生物合成,其抑菌机制与万古霉素(Vancomycin)和替考拉宁(Teicoplanin)不同,但是其对葡萄球菌的抑菌率是万古霉素和替考拉宁的4～8倍,对许多具有耐药性的病原菌也有很好的抑菌效果。同时雷莫拉宁的细胞毒性较小且无交叉耐药问题。雷莫拉宁的纯品是由A1、A2、A33个组分组成的混合物,其中A2为主要成分,占80%。
Ramoplanin （Ramoplanin、A 16686、MDL 62,198） is a new kind of glycopeptide antibiotics, which can inhabit the biosynthesis of the cell walls of gram-positive bacteria specifically and quickly. While the inhibition mechanism of ramoplanin is different from Vancomycin and Teicoplanin, its inhibitory rate against aureus is four to eight times as much as Yancomycin and Teicoplanin, and it shows very good inhibition effects gaginst many pathogens with drug resistance. Meanwhile, the cytotoxicity of Ramoplanin is relative less, and there is no cross resistance problem. Pure Ramoplanin is the maxture of Group A 1, A 2, A 3, and the main components are A 2 which accounts for 80%.
出处
《河北化工》
2008年第9期24-25,34,共3页
Hebei Chemical Industry
关键词
糖肽类抗生素
雷莫拉宁
革兰氏阳性菌
glycopeptide antibiotics；ramoplanin；gram-positive bacteria
