摘要
目的：了解西酞普兰治疗抑郁症的疗效。方法：将60例抑郁症患者随机入组，分为西酞普兰组和阿米替林组．各30例，西酞普兰组最高剂量20～50mg／d，阿米替林组最高剂量100～300mg／d，采用HAMD、CGL、TESS量表，在用药前及用药后2、4、6、8周末评定比较。结果：西酞普兰组和阿米替林组疗效相当，稍优于阿米替林．但差异无显著性（P〈0．05），不良反应西酞普兰以食欲减退，恶心、呕吐为主，阿米替林以口干、便秘、视物模糊、排尿困难、头昏、无力及心电图异常为主。结论：西酞普兰治疗抑郁症疗效较优，不良反应少，使用安全。
Objective：To study the curative effects of citalopram by comparing citalopram with amitriptyline in treating depression. Methods ：60 patients with major depression were divided randomly into two groups：citalopram group and amitriptyline group. The does of amitriptyline group were 100 - 300mg/d, the does of citalopram group were 20 - 60 mg/d. HAMD, CGI, TESS were evaluated before treatment and at the end of 2,4,6,8 weeks after treatment. Results： The effects of citalopram group and amitriptyline group were no significant difference （P 〉 0105 ）. The side effects of citalopram group were loss appetite , nausea, vomiting and those of amitriptyline group were dry mouth, constipation, blurred vision, difficult urination, dizziness, lack strength and ECG abnormality. Conclusions： Citalopram is a safe and satisfied antidepressant, and its side effect is few and wild.
出处
《中国民康医学》
2008年第17期1982-1983,共2页
Medical Journal of Chinese People’s Health
