摘要
目的:米非司酮配伍依沙吖啶用于未产妇中期妊娠引产的有效性和安全性。方法:选择孕16～24周自愿要求终止妊娠而无禁忌证者100例,随机分为两组,A组为观察组50例,米非司酮150mg分3次口服,第二次服药后行依沙吖啶100mg羊膜腔内注射引产,B组为对照组50例,单纯行羊膜腔内注射依沙吖啶100mg引产。观察两组宫颈的改变、宫缩发动时间、总产程时间、软产道损伤、胎盘胎膜残留、产后出血、引产成功率。结果:两组引产成功率均为100%,观察组在宫颈软化程度、宫缩发动时间、总产程时间等方面明显优于对照组(P<0.01),在胎盘胎膜残留、软产道损伤方面,观察组明显低于对照组(P<0.01),产后出血差异无统计学意义(P>0.05)。结论。米非司酮配伍依沙吖啶用于未产妇中期妊娠引产可以加快产程进展,减少并发症。
Objective： To examine the validity and safety of the treatment for induction of labor in mid - pregnancy using mifepristone in combination with rivanol. Methods： 100 women seeking termination of the pregnancy （16 -24 weeks） were allocated to two groups A and B, randomly. The 50 women of group A were administered 150mg mifepristone orally three times a day and followed the induction of labor using intra - amniotic cavity administration of 100mg rivanol after the second oral administration. Another 50 women of the control group B were only administered 100mg rivanol intra - amniotic cavity to terminate pregnancy. Comparing the difference between group A and B, including the changes of cervix uteri, the onset time of u- terine contraction, total stage of labor, soft birth canal injury, placenta and embryolemma residual, postpartum hemorrhage, and the achievement ratio of induction of labor. Results ： The achievement ratios of both groups were 100%. The following situation of group A were better than the control group （P 〈 0.01 ）, including the extent of cervix uteri soften, the onset time of uterine contraction, and total stage of labor. And the placenta and embryolemma residual and soft birth canal injury of group A were obviously lower than the control group （P 〈0. 01 ）. But the difference of postpartum hemorrhage showed no statistical significance （P 〉 0. 05 ）. Conclusion： The usage of mifepristone in combination with rivanol in induction of labor can be recommended for its promotion of birth process and less complication.
出处
《中国计划生育学杂志》
北大核心
2008年第8期490-491,共2页
Chinese Journal of Family Planning
关键词
米非司酮
依沙吖淀
中期妊娠
引产
Mifepristone
Rivanol
Mid - pregnancy
Induction of labor
