摘要
目的:研究胃癌患者肿瘤相关贫血对胃癌患者生存时间的影响。方法:选取2001～2005年病理确诊的术前胃癌患者,通过检索患者住院病历和随访来获取研究资料,应用SPSS软件处理和分析影响胃癌患者预后的因素。结果:669例获生存随访等资料的胃癌患者,术前有无贫血,其生存时间存在显著差异[(23.9±1.7)个月vs.(35.1±2.2)个月,P<0.01];按胃癌TNM分期计算有无贫血患者的生存时间,在Ⅰ期胃癌患者中,无贫血和有贫血患者的生存期分别是(79.9±2.0)个月和(63.5±7.1)个月(P<0.01),但是在Ⅱ期、Ⅲ期和Ⅳ期患者中,未见生存时间存在显著差异(P>0.05)。Cox回归分析表明,有无贫血和胃癌患者预后无显著相关性,而胃癌的肿瘤直径(P=0.009)、肿瘤分化程度(P=0.004)和TNM分期(P<0.001)与胃癌患者预后显著相关。结论:有肿瘤相关性贫血的胃癌患者生存期短于无贫血患者;影响胃癌患者生存期的独立预后因素为肿瘤分期、肿瘤分化程度和肿瘤直径。
Objective：This research was conducted to investigate the correlation between cancer anemia and survival time in patients with gastric carcinoma. Methods：Age,gender, hemoglobin（Hb） ,survival status and disease stage（T,N and M） ,histopatholo- gy type, tumor differentiation and tumor size（diameter） were studied. Descriptive statistics were used to explore sample characteristics and hemoglobin. Chi-square statistics were used to examine differences between dichotomous variables. Kaplan-Meier method was used to explore correlation between anemia status and survival time. Cox regression model was used to evaluate prognostic factors. Results： Six hundred and sixty-nine patients with gastric cancer entered the study. Median survival time （MST） of anemic patients （ AP ） vs. non-anemic patients（NAP） was 23.9 ±1.7 Mon vs. 35.1 ± 2. 2 Mon （P 〈 0.01 ）. In patients with stage I disease, MST of AP vs. NAP was 63.5 ± 7.1 Mon vs. 79. 9± 2.0 Mon（P 〈 0.01 ）. But in patients with stage Ⅱ , Ⅲ and Ⅳ disease, MST had no differences between AP and NAP（ P 〈 0.05 ）. Cox regression model accepted tumor size, tumor differentiation and disease stage as prognostic factors. Conclusion： AP＇s MST was shorter than NAP＇s, but this phenomenon didn＇t appeared in stage 1I ,III and IV disease. Cox regression indicates tumor differentiation and disease stage are prognostic factors of survival time in patients with gastric carcinoma.
出处
《临床肿瘤学杂志》
CAS
2008年第8期704-708,共5页
Chinese Clinical Oncology
基金
"十一五"国家科技支撑计划重大项目(2006BA102A05)
关键词
胃癌
贫血
生存时间
Gastric cancer
Anemia
Survival analysis
