摘要
目的:探讨小剂量氢氯噻嗪与依那普利单用及联合应用治疗高血压患者的临床疗效。方法:96例高血压患者随机分为小剂量氢氯噻嗪组、依那普利组、氢氯噻嗪联合依那普利组,每组32例,疗程4周,比较3组治疗前后降压疗效及达标率。结果:3组血压下降显著(P<0.05),氢氯噻嗪组与依那普利组血压下降比较差异无显著性(P>0.05),联合用药组较单独用药组血压下降更显著(P<0.05)。联合用药组降压有效率75%,达标率71.89%,分别与单独用药组比较P<0.05。结论:小剂量氢氯噻嗪和依那普利单用或联用治疗原发性高血压有效,但两药联用显著提高降压疗效及达标率,联用不良反应减少。
Objective ：To investigate the clinical effect of low dose hydrochlorothiazide and enalapril alone or combination of both in the treatment of essential hypertension.Methods：96 patients with essential hypertension were randomly divided into low dose hydrochlorothiazide group,enalapril group and hydrochlorothiazide and enalapril group,with 32 cases in each group.and treated with the appropriate drugs for 4 weeks.The condition of decreased blood pressure before and after treatment,antihypertensive effect and standardreaching rate were compared among the three groups.Results：After treatment,blood pressure decreased significantly among the three groups （P〈0.05）,there was no obvious difference in decreasing the blood pressure between the hydrochlorothiazide group and enalapril group （P〉05）,but the antihypertensive effect in the drug combination of both was more significant compared with that in two drugs used alone（P〈0.05）.The effective rate of depressurization in the hydrochorothiazide and enalapril group was 75% and its standard-reaching rate was 71.89%,and had significant difference from those in the single administration group （P〈0.05）.Conclusion：Low dose hydrochloroth- iazide and enalapril alone or combination of both in essential hypertension is effective,the drug combination of both can significantly improve the antihypertensive effect and standard-reaching rate, with less adverse reaction.
出处
《现代医药卫生》
2008年第17期2551-2552,共2页
Journal of Modern Medicine & Health
关键词
小剂量氢氯噻嗪
依那普利
高血压
疗效
Low dose hydrochlorothiazide
Enalapril
Essential hypertension
Curative effect
