摘要
目的探讨重度子痫前期合并低蛋白血症对围产结局的影响及其相关性。方法回顾性分析我院2000年1月至2006年3月收治的233例重度子痫前期患者的临床资料，按血清白蛋白检测结果将其分成低蛋白血症组（A组，133例）和非低蛋白血症组（B组，90例），比较两组孕产妇及围产儿结局。结果A组孕妇浆膜腔积液（6．8％和0）、肝酶异常（60．9%和38．9%）、肾功损害（30．1％和11．1％）及并发症（胎盘早剥、产后出血）的发生率（23．3％和11．1％）均高于B组（P〈0．05），新生儿出生体重低于B组[（2192．78±795．31）g和（2454．92±776．24）g，P〈0．05]，围产儿死亡率A组高于B组（26．0％和13．5％）（P〈0．05）。结论重度子痫前期合并低蛋白血症可造成母儿的不良结局，应积极防治。充分细致评估母胎状况，尽可能延长孕周改善新生儿结局，若孕妇重要器官受损或并发难治性浆膜腔积液应适时终止妊娠，以改善孕母结局。
Objective To explore the effects of low serum-albumin on maternal and neonatal outcomes in severe pre-eclampsia. Methods Two hundred and thirty-three women with severe preeclampsia admitted to our hospital from Jan. 2000 to Mar. 2006 were retrospectively investigated and were divided into two groups according to the serum-albumin level：low serum-albumin group （Group A, n= 133） and normal serum-albumin group （Group B, n= 90）. Maternal and fetal outcomes were compared between the two groups. Results The proportion of women with abnormal retention of fluid （6.8%, vs 0）, elevated liver enzymes （60.9% vs 38.9%） renal involvement （30. 1% vs 11.1%） and complications （23.3 % vs 11.1%） （placental abruption and postpartum hemorrhage） in group A were significantly higher than those in group B （all P〈0. 05）. Birth weight in group A was lower than that in group B[（2192.78±795.31） g vs （2454. 92±776.24） g, P〈0. 05] and neonatal mortality in group A was higher （26. 0% vs 13.5%, P〈0.05）. Conclusions Severe pre-eclampsia with low serum-albumin is associated with severe maternal and neonatal outcomes. Appropriate termination of pregnancy should be considered following adequate and careful assessment of maternal and fetal well-being in order to improve perinatal outcomes.
出处
《中华围产医学杂志》
CAS
2008年第4期237-240,共4页
Chinese Journal of Perinatal Medicine
关键词
先兆子痫
低蛋白血症
妊娠结局
Pre-eclampsia
Hypoproteinemia
Pegnancy outcome
