摘要
在１２条麻醉开胸犬上，用微米狭窄器造成冠状动脉前降支临界狭窄。以平均动脉压（ＭＡＰ）、左心室收缩压（ＬＶＳＰ）、左心室舒张压（ＬＶＤＰ）、室内压最大上升速率（ｄｐ／ｄｔｍａｘ）。室内压最大下降速率（－ｄｐ／ｄｔｍａｘ）及心输出量（ＣＯ）等血流动力学指标，观察生脉液在冠脉临界狭窄基础上用药前后心脏功能的改变。结果表明：冠脉临界狭窄时，ＬＶＤＰ明显升高（Ｐ＜０．０５），ＬＶＳＰ、ｄｐ／ｄｔｍａｘ、－ｄｐ／ｄｔｍａｘ及ＣＯ明显降低（Ｐ＜０．０５），提示心功能减弱。而给药后，可使心肌缺血心脏功能的损害减轻。
In 12 open chest mongrel dogs coronary artery critical stenoses were produced by a micrometer constrictor on anterior descending coronary artery.The effect of sheng Mai Ye on the myocardial ischemia model was observed by measuring the mean artery pressure (MAP), the left ventricular diastolic pressure (LVDP), maximal rise in left ventricular pressure (dp/dt max), maximal fall in left ventriculcrr pressure (-dp/dt max) and the cardiac output (CO) etc.The results showed that the LVDP was significantly increased and the MAP、CO、dp/dt max and -dp/dt max were lowered during the period of coronary artery critical stenosis.By taking the herbs in the medicated group, cardiac function was significantly improved.
关键词
生脉液
冠状动脉
临界狭窄
血流动力学
冠心病
sheng mai ye
coronary artery critical stenosis
cardiac haemodynamics
