摘要
将49例有胃食道反流症状、食道pH监测有病理性胃食道反流的患者随机分成两组(其中25例有内镜下食道炎)。一组用雷尼替丁(300mg,2次/d)加西沙必利(5mg,3次/d)(n=25);另一组单用雷尼替丁(300mg,2次/d)(n=24)治疗,疗程4周。结果显示:胃食道反流症状的好转率分别为88.00％、58.33％(P<0.05);食道pH值有效率分别为92.00％、54.17％(P<0.05);内镜下食道炎的愈合率分别为84.62％、50.00％(P>0.05)。以上结果表明:抑制胃酸分泌的药物与促动力剂合用是控制胃食道反流性疾病的最佳方法之一。
Forty nine patients with reflux symptoms and abnormal 24 hour pH monitoring were randomized into two groups, and 25 patients of them endoscopically confirmed reflux esophagitis. One group was treated with ramtidine (300mg/bid) plus cisapride (5mg/tid) (R + C group, N = 25). The other group was treated with ranitidine (300mg/bid) (R group, N = 24). Both groups underwent treatment for four weeks. The symptom relief rate was 88. 00 % in the R + C group and 58. 33 % in the R group (P < 0. 05). The effective rate of esophageal pi I monitoring was 92.00 %, 54.17% (P < 0. 05 ) . The healing rate of esophagitis was 84.62%, 50.00% (P<0.05). The results indicate that ranitidine plus cisapride is more effective than ranitidine in the treatment of gastroesophageal reflux disease.
出处
《中国内镜杂志》
CSCD
1997年第4期9-10,共2页
China Journal of Endoscopy
