摘要
目的探讨p14ARF和p16INK4a蛋白在甲状腺乳头状癌(PTC)中的表达及其与临床病理参数的关系。方法应用免疫组化SP法检测57例PTC、21例甲状腺乳头状微小癌(PTMC)和40例甲状腺腺瘤中p14ARF和p16INK4a蛋白的表达情况。结果p14ARF和p16INK4a蛋白在PTC组的表达阳性率显著低于腺瘤组及PTMC组,差异有统计学意义(分别为P<0.01和<0.05)。p16INK4a蛋白在PTMC组的阳性率明显低于腺瘤组,差异有统计学意义(P<0.05)。PTC组中,p14ARF蛋白表达与淋巴结转移成负相关;p16INK4a蛋白表达与肿瘤复发成负相关,与临床分期成正相关。结论p14ARF和p16INK4a可能参与了PTC的发生和发展,可作为临床判定其生物学行为的辅助指标。
Objective To study the expression of p14^ARF and p16^INK4a protein in thyroid papillary carcinoma （FFC）and its correlation with the clinicopathologic features. Methods Immunohistochemistry was used to detect the expression of the p14^ARF and p16^INK4a protein in 57 PTC specimens,21 thyroid papillary microcarcinoma （PTMC） specimens and 40 thyroid adenoma specimens. Results There were significant difference in expression of p14^ARF and p16^INK4a protein statistically between three groups（P〈0.01 and /9〈0.05）. The positivity rate of p14^ARF and p16^INK4a protein in PTC specimens were significantly lower than that in adenoma specimens （P〈0.01） and PTMC specimens （P〈0.05）. The positivity rate of p16^INK4a protein in PTMC specimens was significantly lower than that in adenoma specimens （P〈0.05）. There was significant relationship between p14^ARF protein expression and lymphnode metastasis in PTC. There were significant relationship between p16^INK4a protein expression and tumor recurrence and clinical stage in PTC. Conclusion Both p14^ARF and p16^INK4a protein probably are involved in the occurrence and development of PTC and may serve as assistant diagnosis for determination of the biological behavior of the tumor.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2008年第4期601-603,共3页
Suzhou University Journal of Medical Science
