摘要
目的:探讨富氧水对急性缺氧大鼠心脏功能和血流动力学的影响。方法:取14只Wistar大白鼠随机分为2组:①低氧组(n=7):低氧模型是将大鼠置于模拟海拔5 400m低压氧舱内3d;②富氧水组(n=7):置于模拟海拔5 400m低压氧舱内,每天早晚各灌服富氧水一次,每次5mL,连续3d。第4d上午在模拟海拔5 400m的低压氧舱内,低氧组和富氧水组动物用10%氨基甲酸乙酯腹腔麻醉,分别经右颈外静脉插入心导管至右心室、肺动脉,用多道生理记录仪连续描记5min肺动脉压力曲线,测定心率(HR)、肺动脉压力(PAP)、右室收缩压(RVSP)和舒张压(RV-EDP)、右室等容收缩期心室内压力上升最大速率和右室等容舒张期心室内压力下降最大速率(±dp/dtmax)等血流动力学指标及心肌超微结构的变化。结果:富氧水组较低氧组HR、RVSP、肺动脉收缩压、肺动脉平均压降低,±dp/dtmax增高,有非常显著性差别(P<0.01或P<0.05);RV-EDP和肺动脉舒张压差别无显著性(P>0.05)。结论:富氧水具有降低肺动脉压,改善血流动力学和心肌传导性的作用。
Objective. To explore the effects of heavy--oxygen--enriched water （HOEW） on heart function and hemodynamics in hypoxic rats. Methods： In a randomized, 14 Wistar rats were divided into hy- poxia control group （n=7） and HOEW gruop（n=7）. All of them were exposed to 5 400m simulated hypobaric chamber for 3 days. HOEW group were drenched with HOEW 5mL per time, twice per day. HR, PAP, RVSP, RVEDP, ±dp/dtmax and cardiac muscle ultrastructure were observed on the 4th day in hypobaric chamber. Results. Compared with control group, HR, RVSP, PAP and ±dp/dtmax in HOEW group increased significantly （P〈0. 01, or P〈0. 05 ）, other items had not significant difference （P〉 0.05）. Conclusions： HOEW can reduce pulmonary artery pressure, improve hemodynamics and myocardial conductibility.
出处
《高原医学杂志》
CAS
2008年第2期5-7,共3页
Journal of High Altitude Medicine
基金
全军"十一五"专项课题(06Z037)
关键词
高原
富氧水
心功能
血流动力学
High altitude
Heavy--oxygen--enriched water
Heart function
Hemodynamics
