摘要
目的改进变构血红蛋白调节剂乙丙昔罗的合成工艺.方法对羟基苯乙酸与3,5-二甲基苯胺在二甲苯中直接回流生成酰胺,后者与氢氧化钾、氯仿在丙酮中回流得乙丙昔罗.结果中间体N-(3,5-二甲苯基)-2-(4-羟基苯基)乙酰胺的收率为86%,产品的收率为85%,合成乙丙昔罗的总收率为73.1%.结论较大程度的降低了生产成本,优化了反应条件,适合于工业化生产.
Objective To improve the synthetic procedure of RSR-13, an allosteric modifiers of hemoglobin. Methods The target compound was synthesized from 2- （4-hydroxyphenyl） acetic acid via refluxing in xylene with 3, 5-dimethylbenzenamine, and the produced N- （3, 5-dimethylphenyl） -2- （4- hydroxyphenyl） acetamider efluxing in acetone with Chloroform and Potassium hydroxide. Results The yield of N- （3, 5-dimethylphenyl） -2- （4-hydroxyphenyl） acetamide was 86%. The yield of efaproxiral was 85%. The overall yield was 73. 1%. Conelusion The advantage of low cost is suitable for industrial production.
出处
《河北北方学院学报（自然科学版）》
2008年第5期19-21,共3页
Journal of Hebei North University:Natural Science Edition
关键词
乙丙昔罗
变构血红蛋白调节剂
工艺改进
合成
efaproxiral
allosteric modifier of hemoglobin
improved synthesis
synthesis
