摘要
目的:通过对5-HT3受体阻断剂,NK-1受体阻断剂,皮质类固醇等药物的研究进展进行阐述,了解用于预防恶心呕吐的药物,为预防和治疗化疗后的恶心呕吐反应寻找或开发出更安全、有效、经济的药物,从而减少或避免在化疗过程中的依从性差,疗效不稳定等情况。方法:通过回顾性研究国内外相关的临床试验和调研相关的文献,展开对其作用机制、药代动力学、临床应用等方面的阐述。结果:5-HT3受体阻断剂和NK-1受体阻断剂对急性呕吐均有较好的疗效,但后者对延迟性呕吐的效果优于前者,而与皮质激素合用疗效会增加,减少不良反应。结论:5-HT3受体阻断剂广泛应用于临床,对急性呕吐有效,但这些止吐药不能做到完全控制化疗引起的恶心呕吐反应(chemotherapy-induced nausea and vomiting,CINV)。
Objective： We explained the investigation of 5-HT3 receptor blocking agents, NK-1 receptor blocking agents, corti-costeroid et al to comprehend nausea and vomiting drugs, which may be helpful for searching and developing safer, more effective and economical drugs to prevent and treat nausea and vomiting. It can also reduce and avoid the poor compliance, instability of curative effects and so on. Methods： We investigated related clinical trials and documents through retrospective study to comprehend mechanism of action, pharmacokinetics and clinical application. Results： 5-HT3 receptor blocking agents and NK-1 receptor blocking a-gents had good curative effects on acute vomiting, but the latter had better effects on tardive vomiting. In addition the effects will be increased and the adverse effects will be reduced when administering with adrenal cortex hormone. Conclusion： Currently the curative effect of 5-HT3 receptor blocking on acute vomiting was relatively positive, and it is widely applied in clinic. These an-tanacathartic can not control the chemotherapy-induced nausea and vomiting （CINV） completely.
出处
《中国药物应用与监测》
CAS
2008年第4期34-38,共5页
Chinese Journal of Drug Application and Monitoring
