摘要
目的:通过考察不同二氯甲烷混合溶剂和不同浓度乙基纤维素(Ethyl cellulose,EC)溶液对制备EC胶囊体的影响,制备符合口服脉冲释药要求的非渗透性胶囊体。方法:采用不同二氯甲烷混合溶剂配制EC溶液,灌注法制备EC胶囊,采用药物溶出仪、片剂硬度计、恒压多功能测厚计、游标卡尺等仪器考察EC胶囊成形的影响因素,通过溶蚀塞片考察与EC胶囊的吻合性。结果:以二氯甲烷/无水乙醇/乙酸乙酯(4/0.8/0.2)为溶剂与EC(45cp)配制11.5%(w/v)的EC溶液,制备EC胶囊体,其各项物理性能符合设计要求,并与溶蚀塞片吻合良好。结论:不同的溶剂和不同浓度的EC溶液对EC胶囊的成形和性能影响显著,使用优化后的条件可制备出符合口服脉冲释药要求的非渗透性EC胶囊。
Objective：To prepare EC impermeable capsule bodies for pulsatile drug delivery system and evaluate the effects of different species dichlormethane mixed solvent and concentration of EC（ ethyl cellulose） solution on EC capsule bodies. Methods：The EC impermeable capsule body was prepared by filling method with the EC solution composed of different dichlormethane mixed solvent. The influencing factors on the forming of the EC capsule and the inosculation between the EC capsule and corrosion tablet were investigated by dissolution tester, hardness tester, muhifunction pachometer and Sliding caliper. Results：The EC capsule body that was prepared by ll.5%（w/v） 45cp EC solution using the mixedsolvent composed of dichlormethane/ethanol absolute/ethyl acetate（4/0.8/0.2） inosculated well with the corrosion tablet and met the requirements of the pulsatile drug delivery system. Conclusions：The solvent and concentration of the EC solution have great impact on the forming and characterisitcs of the capsule bodies,by optimazing the preparing methods, requirements of the oral pulsatile drug delivery system can be met.
出处
《重庆医科大学学报》
CAS
CSCD
2008年第7期858-861,共4页
Journal of Chongqing Medical University
关键词
脉冲胶囊
乙基纤维素
非渗透性胶囊体
脉冲释药
Pulsatile capsule
Ethyl cellulose（EC）
Impermeable capsule
Pulsed release
