摘要
上世纪80年代诞生的组织工程为人类各组织器官的再生带来了希望,利用组织工程技术构建血管成为生产具有无排斥且存在抗凝能力的血管旁路的有利工具。目前,大量的研究为这一构想提供了其实现所需的基础。然而,在内皮细胞的诱导、促进其生长和分布以及功能成熟,血管支架材料的发展和培养环境等问题上仍然存在各种困难,使他们成为组织工程血管应用于临床的瓶颈。目前还没有能够用于临床的组织工程血管,但随着组织工程研究的广泛开展,完全应该相信将来可以利用组织工程构建人体各种器官甚至系统,从而从根本上解决器官移植的供体问题。
The tissue engineering technology that developed in the 1980s brings a hope for the regeneration of human organs. It is feasible to construct by-pass vessels, which have no immune resistance but are capable of anticoagulation. At present, a huge number of researches have provided the necessary basis for the construction. However, there are still some difficulties on the points of induction and proliferation of endothelial cells, development of new materials for scaffold and co-culture of seed cells in scaffold. These difficulties have become the bottle neck of tissue engineered blood vessels. The tissue engineering vessels are nowadays absent in clinical practice. With the progress in researches of tissue engineering, it is strongly believed that human organs and tissues can be constructed using tissue engineering technology, thus satisfying the donors of organ transplantation.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第33期6531-6534,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
