摘要
目的制备磁性阿霉素聚氰基丙烯酸正丁酯纳米粒(ADM-PBCA-MNPS),观察其在正常小鼠体内的靶向分布,为肿瘤的靶向治疗提供一种可能具有临床应用前景的新药。方法采用乳化聚合法制备ADM-PBCA-MNPS。24只昆明小鼠随机分为4组,作相应处理后,尾静脉注射不同药物,观察小鼠体内的靶向分布差异。结果本实验制得了稳定的纳米胶体溶液,平均粒径13.13nm,包封率90.73%,载药量10.68%。ADM-PBCA-MNPS在体外具有良好的磁场响应性,饱和磁化强度为0.558emu/g,且在磁场作用下体内靶向性显著,靶器官靶向指数是非靶器官的3.9倍。结论成功制备ADM-PBCA-MNPS,制备的纳米粒在正常小鼠体内呈靶向聚集分布。
Objective To develop magnetic adriamycin-polybutylcyanoacrylate nanoparticles （ADM- PBCA-MNPS） and observe its targeting effect in mice. To find a potential new drug for the clinical treatment of tumors. Methods We prepared ADM-PBCA^MNPS by emulsion polymerization method, and randomly divided 24 Kunming mice into 4 groups. After corresponding treatment, different drugs were given via tail vein, and the targeting effect was observed. Results We got stable colloid solution ofnanoparticlesand. The quantity of drug-loading and entrapment effect of ADM was good. It has a good magnetic response vitro, and a good targeting effect in vivo. Conclusions ADM-PBCA-MNPS was successfully developed, and the nanoparticles demonstrated targeting aggregating distribution.
出处
《中国骨肿瘤骨病》
2008年第4期225-230,共6页
Chinse Journal Of Bone Tumor And Bone Disease
基金
湖北省卫生厅科研基金资助课题(编号JX1B017)
