摘要
目的探讨高血压性脑出血术后患者情感障碍(包括抑郁、焦虑状态)发生情况以及氟哌噻吨+美利曲辛片(商品名:黛力新)的治疗效果。方法对231例脑出血术后1周的患者采用抑郁自评量表(SDS)、焦虑自评量表(SAS)进行评定,筛选其中存在抑郁和焦虑状态的153例患者,采用抽签方式随机分为氟哌噻吨+美利曲辛片治疗组73例和对照组80例。在基础治疗相同的条件下,治疗组患者晨服氟哌噻吨+美利曲辛片1片/d,连续4周。治疗后4周再次进行SDS、SAS评定,并以住院天数观察氟哌噻吨+美利曲辛片治疗的临床效果。对照组患者口服相应剂量的安慰剂(维生素B6)。结果153例中出现单纯抑郁66例(43.1%),单纯焦虑54例(33.5%),同时存在抑郁和焦虑33例(21.6%)。治疗组服药后的SDS、SAS评分[单纯抑郁为(42±6)分,单纯焦虑为(43±7)分,同时抑郁和焦虑为(43±4)和(43±4)分],分别和用药前[单纯抑郁为(59±4)分,单纯焦虑为(63±4)分,同时抑郁和焦虑为(67±7)和(66±6)分]以及对照组[单纯抑郁为(67±9)分,单纯焦虑为(59±10)分,同时抑郁焦虑为(69±7)和(68±6)分]相比,差异有统计学意义(均P<0.05)。治疗组治疗后显效47例(64.4%),好转21例(28.8%)及无效5例(6.8%);对照组分别为6(7.5%),23(28.8%)及51例(63.8%),两组相比差异有统计学意义(P<0.01)。治疗组的平均住院天数为(23±7)d,与对照组(26±7)d相比,差异有统计学意义(P<0.05)。结论高血压性脑出血患者术后抑郁和焦虑的发生率高,早期的药物治疗可明显缓解患者的抑郁和焦虑状态,加速康复。
Objective To investigate the depression and anxiety in patients after hypertensive cerebral hemorrhage operation and to assess the safety and therapeutic effect of Deanxit on the depression and anxiety. Methods 231 patients after hypertensive cerebral hemorrhage operation were assessed by Self-Rating Depression Scale（SDS） and Self-Rating Anxiety Scale（SAS）. Among them 153 patients with depression and anxiety were selected and divided into two groups randomly. One group （ n = 73 ） were treated with Deanxit （treatment group）, The other group（ n = 80 ） as the control group. After 4 weeks the SDS and SAS scope were reassessed to evaluate the safety and effect of the treatment. Results Among the 153 patients, 66 cases（43. 1% ） had depression, 54 cases had anxiety（33. 5% ）, and 33 cases （21.6%） had both depression and anxiety after operation. The scopes of SDS, SAS in treatment group after 4 weeks were reduced to depression 42 ± 6, anxiety 43 ± 7, depression/anxiety 43 ± 4/43 ± 4, respectively, which were different obviously from pre-treatment （ depression 59 ~ 4, anxiety 63 ± 4, depression/anxiety 67 ± 7/66 ± 6, respectively ） and control group （depression 67 ± 9, anxiety 59 ± 10, depression/anxiety 69 ± 7/68 ± 6, respectively ） （P 〈 0. 05 ）. The number of excellent result is 47 cases（64. 4% ）, good result is 21 cases （28. 8% ）, and no change in 5 case （6. 8% ） in the treatment group. The same result in the control groups were 6 cases （7.5%） ,23 cases （28.8%）, and 51 cases （63. 8% ）respectively. There was significant different between the 2 groups. Conclusion Depression and anxiety after operation for hypertensive cerebral hemorrhage are very common, which may reduce the ability of daily life and neurologic rehabilitation. Deanxit is safe and effective to treat such condition.
出处
《中国脑血管病杂志》
CAS
2008年第8期355-358,共4页
Chinese Journal of Cerebrovascular Diseases
关键词
颅内出血
高血压性
外科手术
抑郁
焦虑
抗抑郁药
Intracranial hemorrhage, hypertensive
Surgical procedures, Depression
Anxiety
Antidepressive agents
