摘要
目的探讨溶血尿毒综合征(HUS)的进程、影响预后因素及治疗。方法分析1993年11月-2007年6月收治的23例HUS患儿的临床资料。结果随访时间1个月～15年。存活14例,13例血压、BUN、Cr、尿常规均正常,1例尿常规异常、肾功能不全,其中有2例复发。死亡9例均为重型,其中6例在短期内(3例于急性期,3例于急性期后)放弃治疗,自动出院,分别于病程的第27～48天死亡;另3例持续尿检异常,进展为终末期肾衰竭,分别于病程的第5、8和13个月死亡。结论影响预后的主要因素是病情轻重及是否早期、积极治疗。在急性期采用以对症治疗为主的综合措施,对度过急性期的HUS患儿定期随访,继续治疗,并依据其临床分型和肾病理改变参照小儿肾小球疾病的临床分类、诊断及治疗方案治疗,可明显改善预后。
Objectives To analyze the progress, factors affecting prognosis and treatment of hemolytic uremic syndrome （HUS）. Methods Twenty-three patients with HUS treated from November, 1993 to July, 2007 were in- cluded and retrospectively reviewed. Results There were 14 survived patients, among them 13 had normal blood pres- sure, blood urea nitrogen, creatine and urine analysis on the last follow-up in 2007, 1 had abnormal urine analysis and renal insufficiency and two patients had relapse. Nine who died were classified into severe type. Six of them gave up therapy （3 in acute stage and 3 after acute stage） and died on the 27th to 48th days of the course. Three patients with persistent abnormal urine analysis developed renal failure and died 5, 8 and 13 months respectively after onset. Conclusions The main factors affecting prognosis of HUS are disease severity, prompt and appropriate therapy. Dur- ing acute stage, the comprehensive measures of symptom-relieving treatment should be adopted, regular follow-up and continuous treatment should be given after then. Treatment based on clinical classification and pathological finding may prominently improve the prognosis.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2008年第8期690-693,共4页
Journal of Clinical Pediatrics
基金
南京军区医学科技研究"十一五"计划课题项目(No.06MA151)
关键词
溶血尿毒综合征
诊断
治疗
hemolytic uremic syndrome
diagnosis
treatment
