期刊文献+

高血压患者氧化型低密度脂蛋白自身抗体和高敏C反应蛋白的检测及临床意义

下载PDF
导出
摘要 目的观察高血压患者氧化型低密度脂蛋白自身抗体(Ab-ox-LDL)和高敏C反应蛋白(hs-CBP)的浓度变化及其与高血压的相关关系。方法选取高血压病人89例(高血压组),健康者40例(对照组),应用ELISA双抗体夹心法检测血清中Ab-ox-LDL含量,同时测定hs-CRP浓度,比较2组指标的差异性,并对hs-CRP、Ab-ox-LDL分别与收缩压(SBP)、舒张压(DBP)进行相关性检验。结果高血压组与对照组各检验指标均差异显著(P<0.01),Ab-ox-LDL与SBP、DBP,hs-CRP与SBP、DBP均呈显著正相关(P<0.01)。结论高血压的发生除多种因素参与外,还与Ab-ox-LDL密切相关。
出处 《中国厂矿医学》 2008年第4期481-482,共2页 Chinese Medicine of Factory and Mine
  • 相关文献

参考文献4

  • 1李晓春,陈鹏,朱永良.氧化型低密度脂蛋白自身抗体及其免疫复合物与冠心病的相关性[J].浙江大学学报(医学版),2002,31(5):321-325. 被引量:20
  • 2Arnal JF, Battle T, Menard J, et al. The vasodilatory effect of endogenous nitric oxide is a major counter-regulatory mechanism in the spontaneously hyperten-sive rat [ J ]. J Hypertens, 1993,11:945 - 950. 被引量:1
  • 3Brizzi P,Tonolo G,Bertrand G,et al. Autoantibodies against oxidozed low-density lipoprotein ( ox-LDL ) and LDL oxidation status [ J ]. Clin Chem Lab Med ,2004,42:164 - 170. 被引量:1
  • 4Devaraj S ,Xu DY ,Jialal I. C-reactive protein increases plasminogen activator inhibitor-Ⅰ expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis [ J 1. Circulation ,2003,107:398 - 404. 被引量:1

二级参考文献17

  • 1Jialal I,Devaraj S.Low-density lipoprotein oxidation,antioxidants,and atherosclerosis:a clinical biochemistry perspective [J].Clin Chem,1996,42(2):498-506. 被引量:1
  • 2Steinberg D,Parthasarathy S,Carew T E,et al.Beyond cholesterol:modification of low-density lipoprotein that increase its atherogenicity [J].N Engl J Med,1989,320(4):915-924. 被引量:1
  • 3Cox D A,Cohen M L.Effects of oxidized low-density lipoprotein on vascular contraction and relaxation:clinical and pharmacological implications in atherosclerosis [J].Pharmacol Rev,1996,48(1):3-19. 被引量:1
  • 4Witztum J L. Immunological response to oxidized LDL [J].Atherosclerosis,1997,131:S9-11. 被引量:1
  • 5Hansson G K.Cell-mediated immunity in atherosclerosis [J].Curr Opin Lipidol,1997,8(2):301-311. 被引量:1
  • 6Bui M N,Sack M N,Moutsatsos G,et al.Autoantibody titers to oxidized low-density lipoprotein in patients with coronary atherosclerosis [J].Am Heart J,1996,131(4):663-667. 被引量:1
  • 7Salonen J T,Herttuala S P,Yamamoto R,et al.Autoantibody against oxidised LDL and progression of carotid atherosclerosis [J].Lancet,1992,339(5):883-887. 被引量:1
  • 8Maggi E,Chiesa R,Melissano G,et al. LDL oxidation in patients with severe carotid atherosclerosis:a study in vitro and in vivo oxidation marker [J]. Arterioscler Thromb,1994,14(4):1892-1899. 被引量:1
  • 9Uusitupa M I,Niskanen L,Luoma J,et al. Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus [J]. Arterioscler Thromb Vasc Biol,1996,16(10):1236-1242. 被引量:1
  • 10Schumacher M,Eber B,Tatzber F,et al. Transient reduction of autoantibodies against oxidized LDL in patients with acute myocardial infarction [J]. Free Radic Biol Med,1995,18(8):1087-1091. 被引量:1

共引文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部