摘要
目的了解健康人群和非呼吸道炎症患者口咽部真菌携带概率及其数量。方法同时采用半定量培养"12级法"和涂片"7级法",对健康人群和非呼吸道炎症患者的口咽部真菌携带状况进行调查。结果健康人群真菌培养、涂片的阳性率分别为4.7%、0.3%,非呼吸道炎症患者真菌培养、涂片的阳性率分别为0.137%、0.013%,非呼吸道炎症人群(包括健康人群和非呼吸道炎症患者)真菌培养、涂片的阳性率分别为9.0%、0.8%,三者比较,培养P<0.001,涂片P>0.05。检出的真菌均为念珠菌。数量均≤少量。非呼吸道炎症人群的≤1个月、10～29岁、30～49岁、≥50岁组的念珠菌培养阳性率递增,分别为2.9%、2.5%、5.8%、17.5%,≥50岁组与≤49岁组比较,P<0.001。结论健康人群和非呼吸道炎症患者口咽部的念珠菌培养阳性率差别明显,只宜综合而不宜单独用作病例对照;若从自然咳出的痰液标本中检出念珠菌以外的其它真菌,宜作可疑感染菌对待;口咽部携带的念珠菌,视为正常菌群还是带菌状态,尚待讨论;临床痰液标本中的念珠菌数量如果大于少量,提示数量增加,有感染的可能;真菌感染的危险性有随年龄增大而增加的趋势,尤以≥50岁组人群为甚;真菌半定量培养的灵敏度高于涂片,而特异度低于涂片。
Objective Understand probability and its quantity of fungus taken at oropharynx of health crowd and sufferer of breathing way not is inflamed,Methods At the same time adoptting 12 order method used for cultivation and 7 order method used for smear, fungus taken Conditions at oropharynx of health crowd and sufferer of breathing way not is inflamed are investigate. Results Positive rates of fungus cultivated and smeared on health crowd are 4.7% and 0.3% respectively. Positive rates of fungus euhivated and smeared on stfferer of breathing way not is inflamed are 13.7% and 1.3% respectively. Positive rates of fungus cultivated and smeared on crowd of breathing way not is inflamed（ to include health crowd and sufferer of breathing way not is inflamed）are 9 % and 0,8% respectively. Effects to compare the three are P 〈 0.001 （cultivate） and P 〉 0.05（smear）,Fungus of the detected all is candida and small quantity. In the crowd of breathing way not is inflamed, candida positive rates of ≤ 1 month, 10～29,30～49 and ≥50 years old increase gradually and respectively are 2.9% ,2. %,5,8%,17.5% .To eompare≥50 with ≤49 years old,effect is P 〈 0.001 .Conclusion Positive rates of candida cultivated at oropharynx to compare health crowd with sufferer of breathing way. not is inflamed, effect dirtier obviously,should only synthetiely but not proper alone used to vase reference, If from sputum of nature coughing out detect other fungus excluding eandida,ean regard as suspicious infectious mold. Candida in oropharynx seen as normal biota or carrier fitting still need discussioun, If candida quantity in squtum larger than little amount, hint its quantity increment and patient possible infected. Risk of one infected fungus aiong with age augment ,crowd of≥50 years old to show up particularly.Sensitivity of fungus cultivated with half fixed amount higher than smear but its specificity lower than smear.
出处
《四川医学》
CAS
2008年第8期1092-1094,共3页
Sichuan Medical Journal
关键词
健康人群
非呼吸道炎症患者
真菌
半定量
hcahh crowd
sufferer of breathing way not is inflamed
fungus
half fixed amount
