摘要
目的探讨直肠癌根治性切除术后局部复发的危险因素。方法回顾性分析2000年1月至2005年12月该院收治的行直肠系膜全切除(TME)的直肠癌69例临床资料,采用病理大切片技术检测直肠系膜转移及环周切缘情况,分析局部复发与临床病理的关系。结果直肠癌根治性切除术后局部复发率为11.6%(8/69)。局部复发与肿瘤直径(P=0.011)、浸润深度(P=0.021)、分化程度(P=0.001)、癌性穿孔(P=0.013)、淋巴结转移(P=0.041)、脉管侵袭(P=0.014)、环周切缘情况(P=0.005)和Dukes分期(P=0.018)密切相关,与病人性别、年龄、肿瘤部位、系膜转移和手术方式不相关(P>0.05)。结论肿瘤直径、浸润深度、分化程度、癌性穿孔、淋巴结转移、脉管侵袭、环周切缘情况和Dukes分期是直肠癌根治性切除术后局部复发的重要因素。
[Objective] To investigate the risk factors of local recurrence after curative resection in patients with rectal carcinoma. [Methods] Cancer specimens from 69 patients with rectal carcinoma who received total mesorectal excision. The relationship between mesorectal metastasis/circumferential resectionmargin status and local recurrence was identified. The relationship between local recurrence and clinicopathologic characteristics of rectal carcinoma was evaluated. [ Results ] Local recurrence after curative resection occurred in 11.6% （8/69） of patients with rectal carcinoma. Local recurrence was associated with tumor size （P =0.011）, infiltrating depth （P =0.021）, tumor differentiation （P =0.001）, cancerous perforation （P =0.013）, lymph node metastasis （P =0.041）, vessel cancerous emboll （P =0.014）, circumferential resection margin status （P =0.005） and Dukes staging （P =0.018）, but had no association with patients＇ sex and age, tumor position, mesorectal metastasis and modus operandi. [ Conclusions ] The resuits demonstrate that tumor size, infiltrating depth, tumor differentiation, cancerous perforation, lymph node metastasis, vessel cancerous emboli, circumferential resection margin status and Dukes staging are significant risk factors of local recurrence after curative resection in patients with rectal carcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第15期2245-2247,共3页
China Journal of Modern Medicine
关键词
直肠癌
根治性切除术
复发
rectal carcinoma
curative resection
recurrence
