摘要
目的:观察三七胶囊对慢性脑缺血患者认知功能障碍的影响。方法:选择符合纳入标准的慢性脑缺血并认知功能障碍患者70例,按随机分组表入组,观察组35例,对照组35例。两组患者均采用常规治疗方法,观察组在上述基础上给予三七胶囊治疗。认知功能障碍疗效评估采用简易智力状况检查法及长谷川痴呆量表,脑血流评估采用经颅多普勒检查分析。结果:70例患者全部进入结果分析。治疗后观察组简易智力状况检查法和长谷川痴呆量表积分较治疗前及治疗后对照组提高(P<0.01或P<0.05);两组简易智力状况检查法和长谷川痴呆量表积分治疗前后差值均数比较差异有显著性(P<0.01)。经颅多普勒检查评估脑血流观察组均优于对照组(P<0.01或P<0.05)。结论:三七胶囊具有改善慢性脑缺血患者认知功能,机制可能与其改善脑血流和血液流变学等作用有关。
Objective ： To observe the influence of Sanqi Capsule on the cognitive disorder of patients with chronic cerebral ischemia. Methods： The experiment was carried out among 70 inpatients from Jan 2005 to Dec 2007. Subjects who were diagnosed as chronic cerebral ischemia with cognitive disorder were randomly allocated into observation group and control group, each containing 35 patients. Both groups received routine treatment for controlling blood pressure and symptomatic treatment, mean while, Piracetarm 0. 8, t. i. d, Aspirin 100mg, q. d, observation group received Tongshu capsule, 3g, b. i. d. Thirty days were taken as a cours~ of treat- ment, and totally for 2 courses. Cognitive disorder was assessed with mini - mental state examination （MMSE） and Hierarchic dementia scale （HDS）, while Trans Cranial Doppler （TCD） was used to measure the cerebral blood flow. Results： All 70 patients were involved in the result analysis. （1）There was no significant difference in the grneral data between the two groups, including age, gender, course of disease （P 〉 0. 05）. （2）MMSE and HDS scores were higher in observation group posttreatment than in observation group pre -treatment and control group post - treatment （P 〈0. 01 or 0. 05）. As for the comparison of pre - treatment and post - treatment, there were significant differences in the mean value of deviation between two groups （P 〈0.01）.（3）TCD result showed that cerebral blood flow was better in observation group than in control group （ P 〈 0.01 or 0. 05 ）. Conclusion ： Sanqi Capsule can improve the cognitive function of patients with chronic cerebral ischemia, and the mechanism may be related to the changes of cerebral blood flow and hemorheology.
出处
《云南中医学院学报》
2008年第4期53-56,共4页
Journal of Yunnan University of Traditional Chinese Medicine
关键词
三七
胶囊剂
慢性脑缺血
认知障碍
Sanqi
Chronic Cerebral Ischemia
The Cognitive Disorder
