摘要
肿瘤细胞耐药性的产生是导致肿瘤化疗失败的重要因素,其产生的机制尚未完全清楚。研究发现,PI3K/Akt通路不仅与细胞的增殖、凋亡有关,而且在肿瘤的生长、对化疗的反应方面都扮演着重要角色。特异性抑制PI3K/Akt通路的活性可减少肿瘤细胞的化疗耐药性,通路抑制剂联合化疗可增强化疗效果,这提示了PI3K/Akt通路可作为肿瘤治疗的潜在靶点。
A major problem in chemotherapy was resistance to the chemotherapeutic agents, and the mechanisms of chemoresistance remained poorly understood. PI3 K/Akt signaling is associated with both of cell proliferation and apoptosis,and plays a major role not only in tumor growth but also in potential response of a tumor to cancer chemotherapy. Specific inhibition of the activation of PI3K/Akt signaling may overcome the resistance to chemotherapy of cancer cells. Therefore, combination of inhibitor with various cytotoxic drugs enhances the effectiveness of the treatments, and suggested that the PI3 K/Akt can be considered as the potential target for tumor therapy.
出处
《医学综述》
2008年第16期2438-2440,共3页
Medical Recapitulate
