摘要
目的探讨肾病综合征（NS）患儿细胞免疫功能的变化及其意义。方法应用流式细胞仪检测45例NS患儿及30例健康对照组外周血T淋巴细胞亚群及自然杀伤细胞（NK）的水平。结果NS患儿活动期CD3^＋、CD4^＋、CD4^＋／CD8^＋比值、NK[CD（16＋56）]^＋细胞均明显低于NS缓解期和对照组（P〈0．05），缓解期CD4^＋细胞明显低于对照组（P〈0．05）。结论NS的发病与细胞免疫功能紊乱密切相关，这为调节患儿免疫功能的相关治疗提供一定依据。
Objective To study the evolution and significance of cellular immune function in the Children with nephrotic syndrome. Methods The level of peripheral blood T lymphocyte, netural killer in the children with nephrotic syndrome（ n = 45） and normal controls group （ n = 30 ） were detected by flow cytometry. Results The percentage of CD3^＋ cells, CD4^＋ cells, CD^＋（16 ＋ 56） cells and the ratio of CD4^＋/CD8^＋ were significantly lower at nephrotic syndrome active stage than those in nephrotic syndrome catahasis stage and normal controls group （P 〈 0.05 ）, the percentage of CD4^＋ cells were significantly lower at nephrotic syndrome catahasis stage than that in normal control group（P 〈 0.05）. Conclusion The invasion of nephrotic syndrome was related to cellular immune function.
出处
《中国基层医药》
CAS
2008年第7期1152-1153,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肾病综合征
免疫
细胞
儿童
Nephrotic syndrome
Immunity,cellular
Child
