摘要
原癌基因Pleiotrophin于1989年被发现，在肿瘤发生发展和中枢神经系统内起着重要作用。最近的研究表明：Pleiotrophin分子信号很可能参与周围神经损伤后脊髓神经元的保护、促进轴突再生、轴突再生导向、骨骼肌的神经再支配4个环节，并可能在轴突再生导向和骨骼肌的神经再支配中发挥关键作用。随着研究的深入，Pleiotrophin基因有望成为提高周围神经修复效果和重建神经肌连接的基因调控靶点。
Pleiotrophin, discovered in 1989, was thought as a multi-functional growth factor; It plays an important role in tumor occurrence and central neural system. The latest research showed pleiotrophin signal pathway probably takes part in neural repair after peripheral nerve injury, especially in the followed crisis point, such as the protection of spinal cord neuron, the promotion of the speed of neuron axon regeneration, the guidance of neuron axon regeneration, skeleton muscle reinnervation. It potentially makes a key role in the guidance of neural axon regeneration in peripheral neural system and muscle reinnervation. Along with the related researches go deep, pleiotrophin gene might become a controllable target for promoting the result of peripheral neural repair and reconstructing the neuromuscular junction.
出处
《国际外科学杂志》
2008年第8期552-556,共5页
International Journal of Surgery
