摘要
【目的】探讨埃索美拉唑治疗反流性食管炎的疗效及对生活质量的影响。【方法】将符合反流性食管炎诊断标准的患者分为埃索美拉唑观察组(n=30,40 mg,1次/d)和奥美拉唑对照组(n=28,20 mg,2次/d),疗程均为8周。治疗前后分别作出胃镜及症状评价,并采用SF-36健康调查量表评定治疗前后的生活质量。【结果】治疗8周后,治疗组胃镜下疗效(96.7%)优于对照组(75.0%),有显著性差异(P<0.05);两组治疗后烧心、反酸、胸骨后灼痛症状评分均有改善,观察组各项症状评分改善优于对照组,差异有显著性(P<0.05);治疗8周后,观察组生理职能、总体健康、躯体疼痛、情感职能、精神健康,对照组的躯体疼痛、精神健康维度评分较治疗前显著提高,差异有显著性意义(P<0.05)。【结论】埃索美拉唑治疗反流性食管炎的疗效明显优于奥美拉唑,并可改善患者的生活质量。
[Objective] To investigate the efficacy of esomeprazole for the treatment of reflux esophagitis and its effect on patients＇quality of life. [Methods] The patients were divided into two groups at random, which esomeprazole group（ n= 30） were given 40mg esomeprazole once a day for 8 weeks and omeprozole group（ n = 18） were given 20mg omeprozole twice a day for 8 weeks. The gastroscope and symptom observation were given before and after treatment respectively. The quality of life was assessed through SF-36 health survey scales before and after treatment. [Results]After 8-week treatment, the efficacy in treatment groups was higher than that in the control group （ P 〈0.05）. In the treatment group, the symptom index of heartburn, reverse acid, post-sternum causalgia had obvious improvement. In the control group, the index of heart- burn and mental health were obviously improved. There was a significant difference between two groups （ P 〈 0. 05）. [Conclusion] The efficacy of the esomeprazole for the treatment of reflux esophagitis is obviously better than that of omeorozole and can improve the patients＇ quality of life.
出处
《医学临床研究》
CAS
2008年第8期1421-1422,1425,共3页
Journal of Clinical Research
