摘要
【目的】寻找北京地区影响先天性甲状腺功能减低症发生的危险因素。【方法】采用1：4的配比病例对照研究，对52名病例和匹配的208名对照父母进行可能危险因素的问卷调查。【结果】病例组母亲孕早期药物和化学品暴露史明显高于对照组，暴露的比值比OR值在4～7之间，为中度相关，并且关联的强度有明显的性别差异。【结论】母亲在妊娠早期用药和接触化学品可能是导致子代发生先天性甲状腺功能减低症的危险因素，并且男性胎儿对不良环境因素更为敏感，女性受到环境和遗传的双重影响。
[Objective] To explore the risk factors of congenital hypothyroidism（CH） in Beijing. [Methods] The parents of 52 cases and 208 normal newborns were selected by 1 ： 4 matched case-control study to finished the questionnaire face to face, the questionnaire included some possible risk factors of CH. [Results] During early pregnancy, the moth ers in case group had more drug and chemical exposure history than control group,the OR values were between 4-7, and showed significant sexual difference. [Conclusions] Mothers＇ exposures to drug and chemical during the early pregnancy, may be the the risk factors of congenital hypothyroidism in offspring. And the male fetus are more sensitive to adverse environmental factors,and the female subject are sensitive to environmental and genetic effects of the double.
出处
《中国儿童保健杂志》
CAS
2008年第4期412-413,共2页
Chinese Journal of Child Health Care
