摘要
目的观察西酞普兰治疗冠心病抑郁障碍的疗效。方法冠心病伴发抑郁障碍患者48例,随机分为治疗组(32例)与对照组(16例)。治疗组给予西酞普兰治疗,起始剂量20mg/日,于早饭后口服,如疗效不佳,可于治疗2周或3周末适当增加日剂量,最高日剂量为60mg,总疗程为6周;对照组采用常规药物治疗。治疗6周评定疗效。结果治疗组患者6周后抑郁指数、HAMD、抑郁情绪改善情况、躯体情况、临床总有效率均优于对照组。结论西酞普兰治疗冠心病抑郁障碍疗效肯定,服用方便,起效快,依从性好,副作用少。
Objective To observe and analyze the clinical effect of Citalopram on depression accompanying with coronary heart disease. Methods 48 cases accompanied with depression were divided into two groups randomly： the treatment group（n=32） and control group（n=16）. The treatment group were given Citalopram at an initial dose of 20mg a day after breakfast besides the regular medicine and cure given by the coronary physician. If the ideal effect can＇t be obtained, daily dose may be increased appropriately, not more than 60mg, two or three weeks. The total period of treatment is six weeks. The control group were given conventional drugs. The effects were evaluated after six weeks. Results After treating for six weeks, the depression index, HAMD,the situation of improved depression, body or physical condition and clinical total efficiency of the treatment group were better than that of the control group. Conclusion Citalopram is effective and safe in the treatment on depression accompanying with coronary heart disease. It can be taken conveniently and has the characteristics of faster onset of action, better compliance, fewer side effects.
出处
《青岛医药卫生》
2008年第4期246-247,共2页
Qingdao Medical Journal
关键词
西酞普兰
冠心病
抑郁障碍
Citalopram
Coronary heart disease
Depressive disorder
